Literature DB >> 20855978

The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.

Peter Zylbergold1, Nitya Ramakrishnan, Terence Hebert.   

Abstract

Kir3 channels (also known as GIRK channels) are important regulators of electrical excitability in both cardiomyocytes and neurons. Much is known regarding the assembly and function of these channels and the roles that their interacting proteins play in controlling these events. Further, they are one of the best studied effectors of heterotrimeric G proteins in general and Gβγ subunits in particular. However, our understanding of the roles of multiple Gβγ binding sites on Kir3 channels is still rudimentary. We discuss potential roles for Gβγ in channel assembly and trafficking in addition to their known role in cellular signaling.

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Year:  2010        PMID： 20855978      PMCID： PMC3051875          DOI： 10.4161/chan.4.5.13327

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


  124 in total

1.  Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors.

Authors:  J K Scott; S F Huang; B P Gangadhar; G M Samoriski; P Clapp; R A Gross; R Taussig; A V Smrcka
Journal:  EMBO J       Date:  2001-02-15       Impact factor: 11.598

2.  Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3.

Authors:  T M Jelacic; S M Sims; D E Clapham
Journal:  J Membr Biol       Date:  1999-05-15       Impact factor: 1.843

3.  Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.

Authors:  Rona Sadja; Noga Alagem; Eitan Reuveny
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-17       Impact factor: 11.205

4.  Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.

Authors:  Catherine E Fowler; Prafulla Aryal; Ka Fai Suen; Paul A Slesinger
Journal:  J Physiol       Date:  2006-12-21       Impact factor: 5.182

5.  Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking.

Authors:  Denis J Dupré; Mélanie Robitaille; Nathalie Ethier; Louis R Villeneuve; Aida M Mamarbachi; Terence E Hébert
Journal:  J Biol Chem       Date:  2006-09-07       Impact factor: 5.157

6.  Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s.

Authors:  Alessandra Baragli; Maria-Laura Grieco; Phan Trieu; Louis R Villeneuve; Terence E Hébert
Journal:  Cell Signal       Date:  2007-11-22       Impact factor: 4.315

Review 7.  Polyamines as gating molecules of inward-rectifier K+ channels.

Authors:  D Oliver; T Baukrowitz; B Fakler
Journal:  Eur J Biochem       Date:  2000-10

8.  Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels.

Authors:  C L Huang; Y N Jan; L Y Jan
Journal:  FEBS Lett       Date:  1997-04-01       Impact factor: 4.124

9.  Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

Authors:  Scott Pegan; Christine Arrabit; Wei Zhou; Witek Kwiatkowski; Anthony Collins; Paul A Slesinger; Senyon Choe
Journal:  Nat Neurosci       Date:  2005-02-20       Impact factor: 24.884

10.  Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma.

Authors:  Moran Rubinstein; Sagit Peleg; Shai Berlin; Dovrat Brass; Tal Keren-Raifman; Carmen W Dessauer; Tatiana Ivanina; Nathan Dascal
Journal:  J Physiol       Date:  2009-05-26       Impact factor: 5.182
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  9 in total

Review 1.  Genetic defects in the hotspot of inwardly rectifying K(+) (Kir) channels and their metabolic consequences: a review.

Authors:  Bikash R Pattnaik; Matti P Asuma; Ryan Spott; De-Ann M Pillers
Journal:  Mol Genet Metab       Date:  2011-10-19       Impact factor: 4.797

Review 2.  Ionic conductances regulating the excitability of colonic smooth muscles.

Authors:  Sang Don Koh; S M Ward; K M Sanders
Journal:  Neurogastroenterol Motil       Date:  2012-06-24       Impact factor: 3.598

3.  Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells.

Authors:  Antonella Maffei; Ann Marie Segal; Juan Carlos Alvarez-Perez; Adolfo Garcia-Ocaña; Paul E Harris
Journal:  Mol Endocrinol       Date:  2015-03-09

4.  Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.

Authors:  Uri Kahanovitch; Vladimir Tsemakhovich; Shai Berlin; Moran Rubinstein; Boaz Styr; Ruth Castel; Sagit Peleg; Galit Tabak; Carmen W Dessauer; Tatiana Ivanina; Nathan Dascal
Journal:  J Physiol       Date:  2014-11-10       Impact factor: 5.182

5.  Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.

Authors:  Shai Berlin; Vladimir A Tsemakhovich; Ruth Castel; Tatiana Ivanina; Carmen W Dessauer; Tal Keren-Raifman; Nathan Dascal
Journal:  J Biol Chem       Date:  2011-07-27       Impact factor: 5.157

Review 6.  The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.

Authors:  Hana Kim; Jinsung Kim; Jae-Pyo Jeon; Jongyun Myeong; Jinhong Wie; Chansik Hong; Hyun Jin Kim; Ju-Hong Jeon; Insuk So
Journal:  Channels (Austin)       Date:  2012-08-10       Impact factor: 2.581

7.  Kir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking.

Authors:  Peter Zylbergold; Rory Sleno; Shahriar M Khan; Ashley M Jacobi; Mark A Belhke; Terence E Hébert
Journal:  Front Cell Neurosci       Date:  2014-04-14       Impact factor: 5.505

8.  A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Authors:  Daniel Yakubovich; Shai Berlin; Uri Kahanovitch; Moran Rubinstein; Isabella Farhy-Tselnicker; Boaz Styr; Tal Keren-Raifman; Carmen W Dessauer; Nathan Dascal
Journal:  PLoS Comput Biol       Date:  2015-11-06       Impact factor: 4.475

Review 9.  Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection.

Authors:  Zesergio Melo; Cecilia Ishida; Maria de la Paz Goldaraz; Rocio Rojo; Raquel Echavarria
Journal:  Noncoding RNA       Date:  2018-09-17
  9 in total

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