Literature DB >> 20854788

Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies.

Roman Davydov1, Brian M Hoffman.   

Abstract

This review describes the use of cryoreduction/annealing EPR/ENDOR techniques for determining the active oxidizing species in reactions catalyzed by heme monooxygenases. The three candidate heme states are: ferric peroxo, ferric hydroperoxo and compound I intermediates. The enzymes discussed include cytochromes P450, nitric oxide synthase and heme oxygenase.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20854788      PMCID： PMC3021649          DOI： 10.1016/j.abb.2010.09.013

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  63 in total

1.  Probing the oxyferrous and catalytically active ferryl states of Amphitrite ornata dehaloperoxidase by cryoreduction and EPR/ENDOR spectroscopy. Detection of compound I.

Authors:  Roman Davydov; Robert L Osborne; Muralidharan Shanmugam; Jing Du; John H Dawson; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2010-10-27       Impact factor: 15.419

2.  Horseradish peroxidase compound I: evidence for spin coupling between the heme iron and a 'free' radical.

Authors:  C E Schulz; P W Devaney; H Winkler; P G Debrunner; N Doan; R Chiang; R Rutter; L P Hager
Journal:  FEBS Lett       Date:  1979-07-01       Impact factor: 4.124

Review 3.  P450 enzymes: their structure, reactivity, and selectivity-modeled by QM/MM calculations.

Authors:  Sason Shaik; Shimrit Cohen; Yong Wang; Hui Chen; Devesh Kumar; Walter Thiel
Journal:  Chem Rev       Date:  2010-02-10       Impact factor: 60.622

Review 4.  Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase.

Authors:  Toshitaka Matsui; Mari Iwasaki; Ryota Sugiyama; Masaki Unno; Masao Ikeda-Saito
Journal:  Inorg Chem       Date:  2010-04-19       Impact factor: 5.165

5.  Substrate modulation of the properties and reactivity of the oxy-ferrous and hydroperoxo-ferric intermediates of cytochrome P450cam as shown by cryoreduction-EPR/ENDOR spectroscopy.

Authors:  Roman Davydov; Roshan Perera; Shengxi Jin; Tran-Chin Yang; Thomas A Bryson; Masanori Sono; John H Dawson; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2005-02-09       Impact factor: 15.419

6.  EPR and ENDOR detection of compound I from Micrococcus lysodeikticus catalase.

Authors:  M J Benecky; J E Frew; N Scowen; P Jones; B M Hoffman
Journal:  Biochemistry       Date:  1993-11-09       Impact factor: 3.162

Review 7.  Hydrocarbon hydroxylation by cytochrome P450 enzymes.

Authors:  Paul R Ortiz de Montellano
Journal:  Chem Rev       Date:  2010-02-10       Impact factor: 60.622

8.  EPR and ENDOR characterization of the reactive intermediates in the generation of NO by cryoreduced oxy-nitric oxide synthase from Geobacillus stearothermophilus.

Authors:  Roman Davydov; Jawahar Sudhamsu; Nicholas S Lees; Brian R Crane; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2009-10-14       Impact factor: 15.419

9.  Reactivities of oxo and peroxo intermediates studied by hemoprotein mutants.

Authors:  Yoshihito Watanabe; Hiroshi Nakajima; Takafumi Ueno
Journal:  Acc Chem Res       Date:  2007-06-14       Impact factor: 22.384

10.  Kinetic isotope effects on the rate-limiting step of heme oxygenase catalysis indicate concerted proton transfer/heme hydroxylation.

Authors:  Roman Davydov; Toshitaka Matsui; Hiroshi Fujii; Masao Ikeda-Saito; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2003-12-31       Impact factor: 15.419
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  30 in total

1.  Resolution and Characterization of Chemical Steps in Enzyme Catalytic Sequences by Using Low-Temperature and Time-Resolved, Full-Spectrum EPR Spectroscopy in Fluid Cryosolvent and Frozen Solution Systems.

Authors:  Miao Wang; Chen Zhu; Meghan Kohne; Kurt Warncke
Journal:  Methods Enzymol       Date:  2015-09-14       Impact factor: 1.600

Review 2.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

Review 3.  Spectroscopic studies of the cytochrome P450 reaction mechanisms.

Authors:  Piotr J Mak; Ilia G Denisov
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2017-06-28       Impact factor: 3.036

Review 4.  Nanodiscs in Membrane Biochemistry and Biophysics.

Authors:  Ilia G Denisov; Stephen G Sligar
Journal:  Chem Rev       Date:  2017-02-08       Impact factor: 60.622

5.  Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy.

Authors:  Roman Davydov; Sangchoul Im; Muralidharan Shanmugam; William A Gunderson; Naw May Pearl; Brian M Hoffman; Lucy Waskell
Journal:  Biochemistry       Date:  2016-02-03       Impact factor: 3.162

6.  Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase.

Authors:  Roman M Davydov; Gareth Jennings; Brian M Hoffman; Larissa M Podust
Journal:  Arch Biochem Biophys       Date:  2019-08-22       Impact factor: 4.013

7.  Identification of a key catalytic intermediate demonstrates that nitrogenase is activated by the reversible exchange of N₂ for H₂.

Authors:  Dmitriy Lukoyanov; Zhi-Yong Yang; Nimesh Khadka; Dennis R Dean; Lance C Seefeldt; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2015-03-05       Impact factor: 15.419

8.  Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.

Authors:  Roman Davydov; Andrey A Gilep; Natallia V Strushkevich; Sergey A Usanov; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2012-10-05       Impact factor: 15.419

9.  Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies.

Authors:  Roman Davydov; Angela S Fleischhacker; Ireena Bagai; Brian M Hoffman; Stephen W Ragsdale
Journal:  Biochemistry       Date:  2015-12-23       Impact factor: 3.162

10.  Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme.

Authors:  Min Dong; Masaki Horitani; Boris Dzikovski; Maria-Eirini Pandelia; Carsten Krebs; Jack H Freed; Brian M Hoffman; Hening Lin
Journal:  J Am Chem Soc       Date:  2016-08-02       Impact factor: 15.419
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