Literature DB >> 20854420

PAPP-A: a new anti-aging target?

Cheryl A Conover1.   

Abstract

This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then reviews data concerning PAPP-A in aging and age-related diseases especially in regard to the PAPP-A knockout (KO) mouse. The PAPP-A KO mouse is a valuable new model to test hypotheses concerning the control of the tissue availability of IGF, independent from systemic levels, on healthspan as well as lifespan.
© 2010 Mayo Clinic. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.

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Year:  2010        PMID： 20854420      PMCID： PMC3047409          DOI： 10.1111/j.1474-9726.2010.00630.x

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   9.304


  52 in total

1.  Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism.

Authors:  Ashok Kumar; Subburaman Mohan; Jacqueline Newton; Mark Rehage; Kiet Tran; David J Baylink; Xuezhong Qin
Journal:  J Biol Chem       Date:  2005-08-22       Impact factor: 5.157

2.  Characterization of four human pregnancy-associated plasma proteins.

Authors:  T M Lin; S P Galbert; D Kiefer; W N Spellacy; S Gall
Journal:  Am J Obstet Gynecol       Date:  1974-01-15       Impact factor: 8.661

3.  The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.

Authors:  J B Lawrence; C Oxvig; M T Overgaard; L Sottrup-Jensen; G J Gleich; L G Hays; J R Yates; C A Conover
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

4.  Pregnancy-associated plasma protein-a is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick chorioallontoic membrane.

Authors:  Julie Jadlowiec; Diana Dongell; Jason Smith; Cheryl Conover; Phil Campbell
Journal:  Endocrinology       Date:  2005-05-26       Impact factor: 4.736

5.  Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies.

Authors:  C A Conover; M C Kiefer; J Zapf
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

6.  Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A.

Authors:  Laurie K Bale; Cheryl A Conover
Journal:  J Endocrinol       Date:  2005-08       Impact factor: 4.286

7.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).

Authors:  J P Liu; J Baker; A S Perkins; E J Robertson; A Efstratiadis
Journal:  Cell       Date:  1993-10-08       Impact factor: 41.582

8.  Characterization and partial purification of the insulin-like growth factor (IGF)-dependent IGF binding protein-4-specific protease from human fibroblast conditioned media.

Authors:  J B Lawrence; L K Bale; T C Haddad; J T Clarkson; C A Conover
Journal:  Growth Horm IGF Res       Date:  1999-02       Impact factor: 2.372

9.  Regulation of insulin-like growth factor binding protein 4 by a specific insulin-like growth factor binding protein 4 proteinase in normal human osteoblast-like cells: implications in bone cell physiology.

Authors:  S K Durham; M C Kiefer; B L Riggs; C A Conover
Journal:  J Bone Miner Res       Date:  1994-01       Impact factor: 6.741

10.  Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells.

Authors:  A Parker; A Gockerman; W H Busby; D R Clemmons
Journal:  Endocrinology       Date:  1995-06       Impact factor: 4.736
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  13 in total

1.  Mice deficient in PAPP-A show resistance to the development of diabetic nephropathy.

Authors:  Jessica R Mader; Zachary T Resch; Gary R McLean; Jakob H Mikkelsen; Claus Oxvig; Ronald J Marler; Cheryl A Conover
Journal:  J Endocrinol       Date:  2013-09-06       Impact factor: 4.286

Review 2.  The somatotropic axis and aging: Benefits of endocrine defects.

Authors:  Andrzej Bartke; Edward O List; John J Kopchick
Journal:  Growth Horm IGF Res       Date:  2016-02-16       Impact factor: 2.372

3.  Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice.

Authors:  Laurie K Bale; Suban Chakraborty; Cheryl A Conover
Journal:  Endocrinology       Date:  2014-02-07       Impact factor: 4.736

4.  Preferential expression of PAPPA in human preadipocytes from omental fat.

Authors:  Caroline Davidge-Pitts; Carlos J Escande; Cheryl A Conover
Journal:  J Endocrinol       Date:  2014-04-29       Impact factor: 4.286

Review 5.  Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.

Authors:  Andrzej Bartke; Liou Y Sun; Valter Longo
Journal:  Physiol Rev       Date:  2013-04       Impact factor: 37.312

6.  Motor and memory testing of long-lived pregnancy-associated plasma protein--a knock-out mice.

Authors:  Emily J Mason; Jacquelyn A Grell; Sally A West; Cheryl A Conover
Journal:  Growth Horm IGF Res       Date:  2014-08-20       Impact factor: 2.372

7.  Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.

Authors:  Weiquan Li; Richard A Miller
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2014-04-01       Impact factor: 6.053

8.  Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress.

Authors:  Min Wang; Richard A Miller
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

9.  Insulin-like growth factor binding proteins: a structural perspective.

Authors:  Briony E Forbes; Peter McCarthy; Raymond S Norton
Journal:  Front Endocrinol (Lausanne)       Date:  2012-03-02       Impact factor: 5.555

10.  Comparative endocrinology of aging and longevity regulation.

Authors:  John B Allard; Cunming Duan
Journal:  Front Endocrinol (Lausanne)       Date:  2011-11-23       Impact factor: 5.555
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