Literature DB >> 2085442

Transforming growth factor-beta inhibits lactogenic hormone induction of beta-casein expression in HC11 mouse mammary epithelial cells.

M Mieth1, F D Boehmer, R Ball, B Groner, R Grosse.   

Abstract

HC11 mouse mammary epithelial cells can undergo a limited functional differentiation in terms of beta-casein synthesis in response to the combined action of dexamethasone and prolactin. Transforming growth factor-beta (TGF-beta) can inhibit beta-casein expression in HC11 cells in a dose-dependent manner. This effect is reversible and specific as shown by comparison with the effect of other growth factors. TGF-beta also inhibits DNA synthesis of HC11 cells. These findings suggest a possible role of TGF-beta as an inhibitor of functional differentiation in the mammary gland.

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Year:  1990        PMID： 2085442     DOI： 10.3109/08977199009011005

Source DB:  PubMed          Journal:  Growth Factors        ISSN： 0897-7194            Impact factor:   2.511


  15 in total

Review 1.  Role of mesenchymal-epithelial interactions in mammary gland development.

Authors:  G R Cunha; Y K Hom
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-01       Impact factor: 2.673

Review 2.  The role of activin in mammary gland development and oncogenesis.

Authors:  Karen A Dunphy; Alan L Schneyer; Mary J Hagen; D Joseph Jerry
Journal:  J Mammary Gland Biol Neoplasia       Date:  2011-04-08       Impact factor: 2.673

3.  Ehrlich ascites tumor cells produce a transforming growth factor-beta (TGFbeta)-like activity but lack receptors with TGFbeta-binding capacity.

Authors:  A Elexpuru; J Martín-Nieto; A Jimenez; C Gómez; A Villalobo
Journal:  Mol Cell Biochem       Date:  1997-05       Impact factor: 3.396

4.  Developmental and environmental regulation of a mammary gland-specific nuclear factor essential for transcription of the gene encoding beta-casein.

Authors:  M Schmitt-Ney; B Happ; R K Ball; B Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

Review 5.  TGF-beta and functional differentiation.

Authors:  G H Smith
Journal:  J Mammary Gland Biol Neoplasia       Date:  1996-10       Impact factor: 2.673

6.  Transforming growth factor-beta 1 inhibits casein secretion from differentiating mammary-gland explants but not from lactating mammary cells.

Authors:  A W Sudlow; C J Wilde; R D Burgoyne
Journal:  Biochem J       Date:  1994-12-01       Impact factor: 3.857

7.  TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution.

Authors:  Brian Bierie; Agnieszka E Gorska; Daniel G Stover; Harold L Moses
Journal:  J Cell Physiol       Date:  2009-04       Impact factor: 6.384

8.  Hormonal induction of functional differentiation and mammary-derived growth inhibitor expression in cultured mouse mammary gland explants.

Authors:  B Binas; E Spitzer; W Zschiesche; B Erdmann; A Kurtz; T Müller; C Niemann; W Blenau; R Grosse
Journal:  In Vitro Cell Dev Biol       Date:  1992 Sep-Oct

9.  EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation.

Authors:  Traci Galbaugh; Maria Grazia Cerrito; Cynthia C Jose; Mary Lou Cutler
Journal:  BMC Cell Biol       Date:  2006-09-19       Impact factor: 4.241

10.  Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

Authors:  C Jhappan; A G Geiser; E C Kordon; D Bagheri; L Hennighausen; A B Roberts; G H Smith; G Merlino
Journal:  EMBO J       Date:  1993-05       Impact factor: 11.598
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