Literature DB >> 20853847

Aldehyde oxidase: an enzyme of emerging importance in drug discovery.

David C Pryde1, Deepak Dalvie, Qiyue Hu, Peter Jones, R Scott Obach, Thien-Duc Tran.   

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Year:  2010        PMID： 20853847     DOI： 10.1021/jm100888d

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  78 in total

1.  Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation.

Authors:  Tapan K Kundu; Murugesan Velayutham; Jay L Zweier
Journal:  Biochemistry       Date:  2012-03-19       Impact factor: 3.162

2.  Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions.

Authors:  John T Barr; Jeffrey P Jones
Journal:  Drug Metab Dispos       Date:  2011-09-22       Impact factor: 3.922

3.  Tales from the war on error: the art and science of curating QSAR data.

Authors:  Marvin Waldman; Robert Fraczkiewicz; Robert D Clark
Journal:  J Comput Aided Mol Des       Date:  2015-08-20       Impact factor: 3.686

4.  Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Authors:  Scott B Hoyt; Whitney Petrilli; Clare London; Gui-Bai Liang; Jim Tata; Qingzhong Hu; Lina Yin; Chris J van Koppen; Rolf W Hartmann; Mary Struthers; Tom Wisniewski; Ning Ren; Charlene Bopp; Andrea Sok; Tian-Quan Cai; Sloan Stribling; Lee-Yuh Pai; Xiuying Ma; Joe Metzger; Andreas Verras; Daniel McMasters; Qing Chen; Elaine Tung; Wei Tang; Gino Salituro; Nicole Buist; Joe Clemas; Gaochao Zhou; Jack Gibson; Carrie Ann Maxwell; Mike Lassman; Theresa McLaughlin; Jose Castro-Perez; Daphne Szeto; Gail Forrest; Richard Hajdu; Mark Rosenbach; Yusheng Xiong
Journal:  ACS Med Chem Lett       Date:  2015-07-17       Impact factor: 4.345

5.  The impact of single nucleotide polymorphisms on human aldehyde oxidase.

Authors:  Tobias Hartmann; Mineko Terao; Enrico Garattini; Christian Teutloff; Joshua F Alfaro; Jeffrey P Jones; Silke Leimkühler
Journal:  Drug Metab Dispos       Date:  2012-01-25       Impact factor: 3.922

6.  Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometry.

Authors:  John T Barr; Jeffrey P Jones; Carolyn A Joswig-Jones; Dan A Rock
Journal:  Mol Pharm       Date:  2013-09-19       Impact factor: 4.939

7.  The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.

Authors:  Catarina Coelho; Martin Mahro; José Trincão; Alexandra T P Carvalho; Maria João Ramos; Mineko Terao; Enrico Garattini; Silke Leimkühler; Maria João Romão
Journal:  J Biol Chem       Date:  2012-09-27       Impact factor: 5.157

8.  Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.

Authors:  Upul K Bandarage; Michael P Clark; Emanuele Perola; Huai Gao; Marc D Jacobs; Alice Tsai; Jeffery Gillespie; Joseph M Kennedy; François Maltais; Mark W Ledeboer; Ioana Davies; Wenxin Gu; Randal A Byrn; Kwame Nti Addae; Hamilton Bennett; Joshua R Leeman; Steven M Jones; Colleen O'Brien; Christine Memmott; Youssef Bennani; Paul S Charifson
Journal:  ACS Med Chem Lett       Date:  2017-01-18       Impact factor: 4.345

Review 9.  Scaffold-hopping as a strategy to address metabolic liabilities of aromatic compounds.

Authors:  Phillip R Lazzara; Terry W Moore
Journal:  RSC Med Chem       Date:  2019-12-16

10.  Why do most human liver cytosol preparations lack xanthine oxidase activity?

Authors:  John T Barr; Kanika V Choughule; Sahadev Nepal; Timothy Wong; Amarjit S Chaudhry; Carolyn A Joswig-Jones; Michael Zientek; Stephen C Strom; Erin G Schuetz; Kenneth E Thummel; Jeffrey P Jones
Journal:  Drug Metab Dispos       Date:  2014-01-15       Impact factor: 3.922
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