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Literature DB >> 20853495

The puzzle of intestinal lamina propria dendritic cells and macrophages.

Abstract

A specialized network of immune cells is positioned directly in the mucosa of the intestinal tract. In this Viewpoint, we discuss the nature and function of DC and macrophages occupying the intestinal lamina propria of mice. DC and macrophages share phenotypic traits and functional plasticity, properties that preclude simple classification of the two cell types. Nevertheless, the information available appears to have reached "critical mass" to allow for a clear demarcation between intestinal macrophages and DC.

Entities: Species

Mesh：

Year: 2010 PMID： 20853495 DOI： 10.1002/eji.201040557

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

37 in total

Review 1. Innate immune signaling in defense against intestinal microbes.

Authors: Melissa A Kinnebrew; Eric G Pamer
Journal: Immunol Rev Date: 2012-01 Impact factor: 12.988

2. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

Authors: Oscar Medina-Contreras; Duke Geem; Oskar Laur; Ifor R Williams; Sergio A Lira; Asma Nusrat; Charles A Parkos; Timothy L Denning
Journal: J Clin Invest Date: 2011-12 Impact factor: 14.808

3. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

Authors: Melissa A Kinnebrew; Charlie G Buffie; Gretchen E Diehl; Lauren A Zenewicz; Ingrid Leiner; Tobias M Hohl; Richard A Flavell; Dan R Littman; Eric G Pamer
Journal: Immunity Date: 2012-02-02 Impact factor: 31.745

10. Characterization of cells expressing lymphatic marker LYVE-1 in macaque large intestine during simian immunodeficiency virus infection identifies a large population of nonvascular LYVE-1(+)/DC-SIGN(+) cells.

Authors: Yang-Kyu Choi; Beth A Fallert Junecko; Cynthia R Klamar; Todd A Reinhart
Journal: Lymphat Res Biol Date: 2013-03 Impact factor: 2.589

The puzzle of intestinal lamina propria dendritic cells and macrophages.

Review 1. Innate immune signaling in defense against intestinal microbes.

2. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.

3. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.

Review 4. Microbial activation of gut dendritic cells and the control of mucosal immunity.

Review 5. Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.

Review 6. Plasmacytoid dendritic cells of the gut: relevance to immunity and pathology.

Review 7. Heterogeneity across the murine small and large intestine.

8. Macrophage Isolation from the Mouse Small and Large Intestine.

Review 9. Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease.

10. Characterization of cells expressing lymphatic marker LYVE-1 in macaque large intestine during simian immunodeficiency virus infection identifies a large population of nonvascular LYVE-1(+)/DC-SIGN(+) cells.