Marco Janner1, Pietro Ballinari, Primus E Mullis, Christa E Flück. 1. Department of Paediatrics, Division of Endocrinology, Diabetology & Metabolism, Children's Hospital, University of Berne, 3010 Bern, Switzerland. marco.janner@insel.ch
Abstract
BACKGROUND: Vitamin D is important for bone health. An inadequate supply of vitamin D to the body is associated with a higher fracture risk in the elderly. Young adults with type 1 diabetes are reported to have a lower peak bone mass than healthy individuals, which could possibly lead to an increased fracture risk in the future. The prevalence of vitamin D deficiency in healthy young people is high. Thus, optimal supply of vitamin D may be of particular importance for bone health in children with type 1 diabetes. METHODS: In this prospective cross-sectional study we measured serum 25-hydroxy-vitamin D, iPTH, total and ionised calcium, phosphate, and alkaline phosphatase in 129 Swiss children and adolescents with type 1 diabetes. RESULTS: Of the 129 subjects 78 (60.5%) were vitamin D deficient, defined as a 25-hydroxy-vitamin-D level below 50 nmol/L. During the winter this number rose to 84.1%. 25-hydroxy-vitamin-D levels showed marked seasonal fluctuations, whereas there was no correlation with diabetes control. Despite the high prevalence of vitamin D deficiency, we found a low prevalence of secondary hyperparathyroidism in vitamin D deficient diabetic children and adolescents. CONCLUSIONS: Prevalence of vitamin D deficiency in diabetic children and adolescents is high. Therefore, screening for vitamin D deficiency and supplementation in children with low vitamin D levels may be considered.
BACKGROUND:Vitamin D is important for bone health. An inadequate supply of vitamin D to the body is associated with a higher fracture risk in the elderly. Young adults with type 1 diabetes are reported to have a lower peak bone mass than healthy individuals, which could possibly lead to an increased fracture risk in the future. The prevalence of vitamin D deficiency in healthy young people is high. Thus, optimal supply of vitamin D may be of particular importance for bone health in children with type 1 diabetes. METHODS: In this prospective cross-sectional study we measured serum 25-hydroxy-vitamin D, iPTH, total and ionised calcium, phosphate, and alkaline phosphatase in 129 Swiss children and adolescents with type 1 diabetes. RESULTS: Of the 129 subjects 78 (60.5%) were vitamin D deficient, defined as a 25-hydroxy-vitamin-D level below 50 nmol/L. During the winter this number rose to 84.1%. 25-hydroxy-vitamin-D levels showed marked seasonal fluctuations, whereas there was no correlation with diabetes control. Despite the high prevalence of vitamin D deficiency, we found a low prevalence of secondary hyperparathyroidism in vitamin Ddeficient diabeticchildren and adolescents. CONCLUSIONS: Prevalence of vitamin D deficiency in diabeticchildren and adolescents is high. Therefore, screening for vitamin D deficiency and supplementation in children with low vitamin D levels may be considered.
Authors: Marjaana Mäkinen; Juha Mykkänen; Maarit Koskinen; Ville Simell; Riitta Veijola; Heikki Hyöty; Jorma Ilonen; Mikael Knip; Olli Simell; Jorma Toppari Journal: J Clin Endocrinol Metab Date: 2015-12-22 Impact factor: 5.958
Authors: K Rose; M Penna-Martinez; E Klahold; D Kärger; F Shoghi; H Kahles; M Bayer; E Hintermann; J M Pfeilschifter; K Badenhoop; E Ramos-Lopez; U Christen Journal: Clin Exp Immunol Date: 2013-02 Impact factor: 4.330