Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

Literature DB >> 20852628

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

Nikita Popov¹, Christina Schülein, Laura A Jaenicke, Martin Eilers.

Abstract

The SCFFbw7 ubiquitin ligase mediates growth-factor-regulated turnover of the Myc oncoprotein. Here we show that SCFβ-TrCP binds to Myc by means of a characteristic phosphodegron and ubiquitylates Myc; this results in enhanced Myc stability. SCFFbw7 and SCFβ-TrCP can exert these differential effects through polyubiquitylation of the amino terminus of Myc. Whereas SCFFbw7 with the Cdc34 ubiquitin-conjugating enzyme specifically requires lysine 48 (K48) of ubiquitin, SCFβ-TrCP uses the UbcH5 ubiquitin-conjugating enzyme to form heterotypic polyubiquitin chains on Myc. Ubiquitylation of Myc by SCFβ-TrCP is required for Myc-dependent acceleration of cell cycle progression after release from an arrest in S phase. Therefore, alternative ubiquitylation events at the N terminus can lead to the ubiquitylation-dependent stabilization of Myc.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20852628 DOI： 10.1038/ncb2104

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

48 in total

1. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

Authors: James DiRenzo; Sabina Signoretti; Noriaki Nakamura; Ramon Rivera-Gonzalez; William Sellers; Massimo Loda; Myles Brown
Journal: Cancer Res Date: 2002-01-01 Impact factor: 12.701

2. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

Authors: R Sears; F Nuckolls; E Haura; Y Taya; K Tamai; J R Nevins
Journal: Genes Dev Date: 2000-10-01 Impact factor: 11.361

3. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

Authors: J T Winston; P Strack; P Beer-Romero; C Y Chu; S J Elledge; J W Harper
Journal: Genes Dev Date: 1999-02-01 Impact factor: 11.361

4. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.

Authors: R Verma; R M Feldman; R J Deshaies
Journal: Mol Biol Cell Date: 1997-08 Impact factor: 4.138

5. BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

Authors: Martin Steegmaier; Matthias Hoffmann; Anke Baum; Péter Lénárt; Mark Petronczki; Martin Krssák; Ulrich Gürtler; Pilar Garin-Chesa; Simone Lieb; Jens Quant; Matthias Grauert; Günther R Adolf; Norbert Kraut; Jan-Michael Peters; Wolfgang J Rettig
Journal: Curr Biol Date: 2007-02-08 Impact factor: 10.834

6. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.

Authors: William E Blanco-Bose; Mark J Murphy; Armin Ehninger; Sandra Offner; Christelle Dubey; Wendong Huang; David D Moore; Andreas Trumpp
Journal: Hepatology Date: 2008-10 Impact factor: 17.425

7. Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.

Authors: Geng Wu; Guozhou Xu; Brenda A Schulman; Philip D Jeffrey; J Wade Harper; Nikola P Pavletich
Journal: Mol Cell Date: 2003-06 Impact factor: 17.970

8. The MYC protein activates transcription of the alpha-prothymosin gene.

Authors: M Eilers; S Schirm; J M Bishop
Journal: EMBO J Date: 1991-01 Impact factor: 11.598

Review 9. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

Authors: David Frescas; Michele Pagano
Journal: Nat Rev Cancer Date: 2008-06 Impact factor: 60.716

10. c-Myc accelerates S-phase and requires WRN to avoid replication stress.

Authors: Kristin Robinson; Nichaya Asawachaicharn; Denise A Galloway; Carla Grandori
Journal: PLoS One Date: 2009-06-18 Impact factor: 3.240

73 in total

Review 1. Ubiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteins.

Authors: Damian D Guerra; Judy Callis
Journal: Plant Physiol Date: 2012-06-22 Impact factor: 8.340

2. Deubiquitinating c-Myc: USP36 steps up in the nucleolus.

Authors: Xiao-Xin Sun; Rosalie C Sears; Mu-Shui Dai
Journal: Cell Cycle Date: 2015 Impact factor: 4.534

3. Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.

Authors: Ji Hoon Jung; Deok-Beom Jung; Hyunseok Kim; Hyemin Lee; Shi-Eun Kang; Sanjay K Srivastava; Miyong Yun; Sung-Hoon Kim
Journal: Oncogene Date: 2018-04-09 Impact factor: 9.867

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.

1. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

2. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

3. The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

4. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.

5. BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

6. C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.

7. Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.

8. The MYC protein activates transcription of the alpha-prothymosin gene.

Review 9. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

10. c-Myc accelerates S-phase and requires WRN to avoid replication stress.

Review 1. Ubiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteins.

2. Deubiquitinating c-Myc: USP36 steps up in the nucleolus.

3. Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.

Review 4. Target gene-independent functions of MYC oncoproteins.

5. Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.

6. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.

7. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

8. Nitric oxide increases lysine 48-linked ubiquitination following arterial injury.

Review 9. Regulation of Normal and Malignant Hematopoiesis by FBOX Ubiquitin E3 Ligases.

10. RNAi screen identifies a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition.