Brian P Vickery1, Wesley Burks. 1. Division of Pediatric Allergy and Immunology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27710, USA. brian.vickery@duke.edu
Abstract
PURPOSE OF REVIEW: Food allergy is a difficult clinical problem for which no disease-modifying therapy currently exists. RECENT FINDINGS: The daily administration of graded allergen doses through oral immunotherapy (OIT) is one promising experimental approach to the development of a clinically available treatment. Although the concept of oral immunologic tolerance is not new, OIT as a treatment for food allergy is innovative. Over the last few years, several groups of investigators have begun to demonstrate safety and varying degrees of efficacy and immune modulation in uncontrolled pilot studies of OIT. Rigorously designed trials are currently underway and important unanswered questions remain. SUMMARY: OIT for food allergy holds promise for patients with food allergy but additional research is necessary before this approach is ready for clinical use.
PURPOSE OF REVIEW: Food allergy is a difficult clinical problem for which no disease-modifying therapy currently exists. RECENT FINDINGS: The daily administration of graded allergen doses through oral immunotherapy (OIT) is one promising experimental approach to the development of a clinically available treatment. Although the concept of oral immunologic tolerance is not new, OIT as a treatment for food allergy is innovative. Over the last few years, several groups of investigators have begun to demonstrate safety and varying degrees of efficacy and immune modulation in uncontrolled pilot studies of OIT. Rigorously designed trials are currently underway and important unanswered questions remain. SUMMARY: OIT for food allergy holds promise for patients with food allergy but additional research is necessary before this approach is ready for clinical use.
Authors: Michiko K Oyoshi; Hans C Oettgen; Talal A Chatila; Raif S Geha; Paul J Bryce Journal: J Allergy Clin Immunol Date: 2014-02 Impact factor: 10.793
Authors: Oliver T Burton; Magali Noval Rivas; Joseph S Zhou; Stephanie L Logsdon; Alanna R Darling; Kyle J Koleoglou; Axel Roers; Hani Houshyar; Michael A Crackower; Talal A Chatila; Hans C Oettgen Journal: Immunity Date: 2014-07-10 Impact factor: 31.745
Authors: Juliana De S Rebouças; Juan M Irache; Ana I Camacho; Gabriel Gastaminza; María L Sanz; Marta Ferrer; Carlos Gamazo Journal: Clin Vaccine Immunol Date: 2014-06-04
Authors: Aleena Syed; Marco A Garcia; Shu-Chen Lyu; Robert Bucayu; Arunima Kohli; Satoru Ishida; Jelena P Berglund; Mindy Tsai; Holden Maecker; Gerri O'Riordan; Stephen J Galli; Kari C Nadeau Journal: J Allergy Clin Immunol Date: 2014-02 Impact factor: 10.793