Patrick J Horner1, David Taylor-Robinson. 1. Department of Social Medicine, School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK. Paddy.horner@bristol.ac.uk
Abstract
OBJECTIVE: To determine whether Mycoplasma genitalium is associated with balanitis and/or posthitis in a previous study of the role of M genitalium in men with acute non-gonococcal urethritis (NGU). METHODS: In a previous study of men with acute NGU, the existence of balanitis and/or posthitis was recorded. Chlamydia trachomatis, M genitalium and ureaplasmas were sought in urethral swabs and urine using a direct fluorescent antibody test and in-house PCR, an in-house PCR and a culture method, respectively. Men were treated with doxycycline or erythromycin. RESULTS: M genitalium was associated significantly (p = 0.01) with balanitis and/or posthitis in 114 men with acute NGU. This association persisted when there was control for C trachomatis and urethral discharge (p = 0.021, OR 4.1, 95% CI 1.2 to 13.5). C trachomatis and ureaplasmas were not associated with balanitis and/or posthitis. CONCLUSION: Detection of M genitalium in men with acute NGU was associated significantly with balanitis and/or posthitis. The association is biologically plausible and may have a role in HIV-1 transmission and susceptibility.
OBJECTIVE: To determine whether Mycoplasma genitalium is associated with balanitis and/or posthitis in a previous study of the role of M genitalium in men with acute non-gonococcal urethritis (NGU). METHODS: In a previous study of men with acute NGU, the existence of balanitis and/or posthitis was recorded. Chlamydia trachomatis, M genitalium and ureaplasmas were sought in urethral swabs and urine using a direct fluorescent antibody test and in-house PCR, an in-house PCR and a culture method, respectively. Men were treated with doxycycline or erythromycin. RESULTS: M genitalium was associated significantly (p = 0.01) with balanitis and/or posthitis in 114 men with acute NGU. This association persisted when there was control for C trachomatis and urethral discharge (p = 0.021, OR 4.1, 95% CI 1.2 to 13.5). C trachomatis and ureaplasmas were not associated with balanitis and/or posthitis. CONCLUSION: Detection of M genitalium in men with acute NGU was associated significantly with balanitis and/or posthitis. The association is biologically plausible and may have a role in HIV-1 transmission and susceptibility.
Authors: Supriya D Mehta; Charlotte Gaydos; Ian Maclean; Elijah Odoyo-June; Stephen Moses; Lawrence Agunda; Nicole Quinn; Robert C Bailey Journal: Sex Transm Dis Date: 2012-04 Impact factor: 2.830
Authors: Aaron A R Tobian; Charlotte Gaydos; Ronald H Gray; Godfrey Kigozi; David Serwadda; Nicole Quinn; Mary K Grabowski; Richard Musoke; Anthony Ndyanabo; Fred Nalugoda; Maria J Wawer; Thomas C Quinn Journal: Sex Transm Infect Date: 2013-11-20 Impact factor: 3.519
Authors: Jimmy Twin; Jorgen S Jensen; Catriona S Bradshaw; Suzanne M Garland; Christopher K Fairley; Lim Yi Min; Sepehr N Tabrizi Journal: PLoS One Date: 2012-04-20 Impact factor: 3.240