| Literature DB >> 20850521 |
Melissa J Perry1, Scott A Venners, Xing Chen, Xue Liu, Genfu Tang, Houxun Xing, Dana Boyd Barr, Xiping Xu.
Abstract
Many Americans are exposed to low levels of organophosphorous (OP) pesticides. It is unclear whether these exposures impact sperm production. We investigated whether there was an association between urinary OP insecticide metabolites and sperm concentration and motility in newly married men from a rural area of eastern People's Republic of China. Ninety-four cases and 95 controls were included based on their median residual value of sperm concentration and motility after adjusting for relevant covariates. Their urine was analyzed for six dialkylphosphate (DAP) compounds. After adjustment for demographic and exposure variables, the odds of being a case were greater (odds ratio=1.30, 95% confidence interval 1.02-1.65) in men with higher urinary concentrations of dimethylphosphate (DMP) compared to men with lower levels. No significant differences between cases and controls were found among the other DAP concentrations. DMP exposure and sperm concentration and motility should be explored further in environmental exposure studies.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20850521 PMCID： PMC3035720 DOI： 10.1016/j.reprotox.2010.08.006
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143