Literature DB >> 20850311

Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.

Zha-Jun Zhan1, Qi Yu, Zhan-Li Wang, Wei-Guang Shan.   

Abstract

Through bioassay-guided fractionation and chromatography technique, eight indole alkaloids were furnished from the stems of Ervatamia hainanensis. All isolates were evaluated for acetylcholinesterase (AChE) inhibition activities, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of Alzheimer's disease. Discussion about the relationships between structure and activity of these alkaloids was also presented. Crown
Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20850311     DOI： 10.1016/j.bmcl.2010.08.123

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

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  8 in total

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