| Literature DB >> 20850302 |
Shikha S Chauhan1, Leena Gupta, Monika Mittal, Preeti Vishwakarma, Suman Gupta, Prem M S Chauhan.
Abstract
A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC(50) value of 5.17μM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine.Entities:
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Year: 2010 PMID： 20850302 DOI： 10.1016/j.bmcl.2010.08.119
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823