BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.
BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.
Authors: Nam P Nguyen; Misty Ceizyk; Jacqueline Vock; Paul Vos; Alexander Chi; Vincent Vinh-Hung; Judy Pugh; Rihan Khan; Christina Truong; Gabby Albala; Angela Locke; Ulf Karlsson; Steve Gelumbauskas; Lexie Smith-Raymond Journal: PLoS One Date: 2013-08-13 Impact factor: 3.240
Authors: Nam P Nguyen; Wei Shen; Sarah Kratz; Jacqueline Vock; Paul Vos; Vinh-Hung Vincent; Gabor Altdorfer; Lars Ewell; Siyoung Jang; Ulf Karlsson; Juan Godinez; Melissa Mills; Thomas Sroka; Suresh Dutta; Alexander Chi Journal: Front Oncol Date: 2013-11-26 Impact factor: 6.244