Literature DB >> 20848071

[Linear localized scleroderma. Successful treatment with prednisolone pulse therapy and methotrexate].

A Pierchalla1, K W Schulte, B Homey.   

Abstract

Linear localized scleroderma is a variant of localized scleroderma characterized by linear bands and sclerotic plaques of the skin, which can result in contractures, muscle atrophy and debilitating deformities. The etiology remains unknown and no specific therapy is available. Regimens combining pulsed high-dose corticosteroids with methotrexate therapy seem promising. Our patient responded well to intravenous prednisolone (500 mg/d) for 3 consecutive days monthly combined with an oral dose of methotrexate of (15 mg/wk).

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Year:  2010        PMID: 20848071     DOI: 10.1007/s00105-010-2047-z

Source DB:  PubMed          Journal:  Hautarzt        ISSN: 0017-8470            Impact factor:   0.751


  6 in total

1.  Methotrexate and corticosteroid therapy for pediatric localized scleroderma.

Authors:  Y Uziel; B M Feldman; B R Krafchik; R S Yeung; R M Laxer
Journal:  J Pediatr       Date:  2000-01       Impact factor: 4.406

2.  [AWMF Guideline no. 013/066. Diagnosis and therapy of circumscribed scleroderma].

Authors:  Alexander Kreuter; Thomas Krieg; Margitta Worm; Jörg Wenzel; Thilo Gambichler; Annegret Kuhn; Elisabeth Aberer; Karin Scharffetter-Kochanek; Nicolas Hunzelmann
Journal:  J Dtsch Dermatol Ges       Date:  2009-09       Impact factor: 5.584

3.  Evaluation of methotrexate and corticosteroids for the treatment of localized scleroderma (morphoea) in children.

Authors:  L Weibel; M C Sampaio; M T Visentin; K J Howell; P Woo; J I Harper
Journal:  Br J Dermatol       Date:  2006-11       Impact factor: 9.302

4.  Pulsed high-dose corticosteroids combined with low-dose methotrexate in severe localized scleroderma.

Authors:  Alexander Kreuter; Thilo Gambichler; Frank Breuckmann; Sebastian Rotterdam; Marcus Freitag; Markus Stuecker; Klaus Hoffmann; Peter Altmeyer
Journal:  Arch Dermatol       Date:  2005-07

5.  Juvenile localised scleroderma: a retrospective review of response to systemic treatment.

Authors:  D Cox; G O' Regan; S Collins; A Byrne; A Irvine; R Watson
Journal:  Ir J Med Sci       Date:  2008-10-21       Impact factor: 1.568

Review 6.  Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis.

Authors:  I Badea; M Taylor; A Rosenberg; M Foldvari
Journal:  Rheumatology (Oxford)       Date:  2008-11-20       Impact factor: 7.580

  6 in total

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