OBJECTIVE: The association between obesity and cardiovascular disease and venous thromboembolism might, at least partially, be explained by a hypercoagulable state. The extent to which body fat mass and its distribution contribute to a hypercoagulable state is unknown. In this study, we investigated the association between body composition and thrombin generation and evaluated the potential mediating role of low-grade inflammation. METHODS AND RESULTS: We studied 586 individuals from the Hoorn Study (mean age, 69.7 ± 6.5 years, 298 women) in whom body composition was assessed by whole body dual-energy absorptiometry. Thrombin generation was measured using the calibrated automated thrombogram. Multiple regression analyses showed a positive association between total body fat and thrombin generation in women but not in men. In addition, detailed analyses of regional body composition showed that central but not peripheral fat mass was associated with greater thrombin generation and that there was a trend toward an inverse association with peripheral lean mass. The reported positive associations were partially attenuated by low-grade inflammation, however. CONCLUSIONS: Body fat mass, in particular a central pattern of fat distribution, is associated with higher levels of thrombin generation in elderly women but not in men. This association may partially be explained by adiposity-related low-grade inflammation, but this hypothesis needs to be further investigated in mechanistic/prospective studies.
OBJECTIVE: The association between obesity and cardiovascular disease and venous thromboembolism might, at least partially, be explained by a hypercoagulable state. The extent to which body fat mass and its distribution contribute to a hypercoagulable state is unknown. In this study, we investigated the association between body composition and thrombin generation and evaluated the potential mediating role of low-grade inflammation. METHODS AND RESULTS: We studied 586 individuals from the Hoorn Study (mean age, 69.7 ± 6.5 years, 298 women) in whom body composition was assessed by whole body dual-energy absorptiometry. Thrombin generation was measured using the calibrated automated thrombogram. Multiple regression analyses showed a positive association between total body fat and thrombin generation in women but not in men. In addition, detailed analyses of regional body composition showed that central but not peripheral fat mass was associated with greater thrombin generation and that there was a trend toward an inverse association with peripheral lean mass. The reported positive associations were partially attenuated by low-grade inflammation, however. CONCLUSIONS: Body fat mass, in particular a central pattern of fat distribution, is associated with higher levels of thrombin generation in elderly women but not in men. This association may partially be explained by adiposity-related low-grade inflammation, but this hypothesis needs to be further investigated in mechanistic/prospective studies.
Authors: Anna K Kopec; Nikita Joshi; Keara L Towery; Karen M Kassel; Bradley P Sullivan; Matthew J Flick; James P Luyendyk Journal: J Pharmacol Exp Ther Date: 2014-08-19 Impact factor: 4.030
Authors: Karen M Kassel; A Phillip Owens; Cheryl E Rockwell; Bradley P Sullivan; Ruipeng Wang; Ossama Tawfik; Guodong Li; Grace L Guo; Nigel Mackman; James P Luyendyk Journal: Am J Pathol Date: 2011-09-09 Impact factor: 4.307
Authors: Ching-Hui Sia; Sock-Hwee Tan; Siew-Pang Chan; Stephanie Marchesseau; Hui-Wen Sim; Leonardo Carvalho; Ruth Chen; Nor Hanim Mohd Amin; Alan Yean-Yip Fong; Arthur Mark Richards; Christina Yip; Mark Y Chan Journal: Pharmaceuticals (Basel) Date: 2022-06-06
Authors: Machiel Smid; Arne W J H Dielis; Henri M H Spronk; Ann Rumley; Rene van Oerle; Mark Woodward; Hugo ten Cate; Gordon Lowe Journal: PLoS One Date: 2013-06-24 Impact factor: 3.240
Authors: Jérémy Lagrange; Mélusine Didelot; Amel Mohamadi; Lucy A Walton; Saartje Bloemen; Bas de Laat; Huguette Louis; Simon N Thornton; Brian Derby; Michael J Sherratt; Bruno Fève; Pascal Challande; Riaz Akhtar; J Kennedy Cruickshank; Patrick Lacolley; Véronique Regnault Journal: Front Physiol Date: 2017-11-22 Impact factor: 4.566