Literature DB >> 20846730

Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.

Nan Gong1, Jianuo Liu, Ashley D Reynolds, Santhi Gorantla, R Lee Mosley, Howard E Gendelman.   

Abstract

CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, relationships between Treg ingress of end organ tissues, notably the brain, and neuroprotection were investigated. Treg from EGFP-transgenic donor mice were expanded, labeled with indium-111, and adoptively transferred. Treg distribution was assayed by single photon emission computed tomography and immunohistochemistry. Treg readily migrated across the blood brain barrier and were retained within virus-induced neuroinflammatory sites. In non-inflamed peripheral tissues (liver and spleen) Treg were depleted. These observations demonstrate that Treg migrate to sites of inflammation where they modulate immune responses.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20846730      PMCID： PMC3003943          DOI： 10.1016/j.jneuroim.2010.08.014

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  61 in total

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4.  Indium-111 labelled lymphocytes: isotope distribution and cell division.

Authors:  J Kuyama; A McCormack; A J George; B T Heelan; S Osman; J R Batchelor; A M Peters
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5.  Human immunodeficiency virus encephalitis in SCID mice.

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  16 in total

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Review 3.  Bridge between neuroimmunity and traumatic brain injury.

Authors:  Matthew L Kelso; Howard E Gendelman
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Review 4.  Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.

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8.  Granulocyte-macrophage colony-stimulating factor mRNA and Neuroprotective Immunity in Parkinson's disease.

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