Literature DB >> 20844553

Harnessing transposons for cancer gene discovery.

Neal G Copeland1, Nancy A Jenkins.   

Abstract

Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating the identification of the genes and signalling pathways that drive tumour formation. A conditional SB transposition system has also been developed that makes it possible to limit where SB mutagenesis occurs, providing a means to selectively model many types of human cancer. SB mutagenesis has already identified a large collection of known cancer genes in addition to a plethora of new candidate cancer genes and potential drug targets.

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Year:  2010        PMID： 20844553     DOI： 10.1038/nrc2916

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  101 in total

1.  Generalized lacZ expression with the ROSA26 Cre reporter strain.

Authors:  P Soriano
Journal:  Nat Genet       Date:  1999-01       Impact factor: 38.330

2.  Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells.

Authors:  Z Ivics; P B Hackett; R H Plasterk; Z Izsvák
Journal:  Cell       Date:  1997-11-14       Impact factor: 41.582

3.  Tagged mutagenesis by efficient Minos-based germ line transposition.

Authors:  Ton de Wit; Sylvia Dekker; Alex Maas; Guido Breedveld; Tobias A Knoch; An Langeveld; Dorota Szumska; Roger Craig; Shoumo Bhattacharya; Frank Grosveld; Dubravka Drabek
Journal:  Mol Cell Biol       Date:  2010-01       Impact factor: 4.272

4.  Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

Authors:  Thomas J Vigdal; Christopher D Kaufman; Zsuzsanna Izsvák; Daniel F Voytas; Zoltán Ivics
Journal:  J Mol Biol       Date:  2002-10-25       Impact factor: 5.469

5.  Regulated transposition of a fish transposon in the mouse germ line.

Authors:  S E Fischer; E Wienholds; R H Plasterk
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-29       Impact factor: 11.205

6.  Chromosomal transposition of a Tc1/mariner-like element in mouse embryonic stem cells.

Authors:  G Luo; Z Ivics; Z Izsvák; A Bradley
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

7.  Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells.

Authors:  Stephen R Yant; Mark A Kay
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

8.  TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

Authors:  L W Ellisen; J Bird; D C West; A L Soreng; T C Reynolds; S D Smith; J Sklar
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

9.  Preferential transposition of Drosophila P elements to nearby chromosomal sites.

Authors:  J Tower; G H Karpen; N Craig; A C Spradling
Journal:  Genetics       Date:  1993-02       Impact factor: 4.562

10.  Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

Authors:  Jennifer O Lauchle; Doris Kim; Doan T Le; Keiko Akagi; Michael Crone; Kimberly Krisman; Kegan Warner; Jeannette M Bonifas; Qing Li; Kristen M Coakley; Ernesto Diaz-Flores; Matthew Gorman; Sally Przybranowski; Mary Tran; Scott C Kogan; Jeroen P Roose; Neal G Copeland; Nancy A Jenkins; Luis Parada; Linda Wolff; Judith Sebolt-Leopold; Kevin Shannon
Journal:  Nature       Date:  2009-09-02       Impact factor: 49.962
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  76 in total

1.  Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf-/- mouse model.

Authors:  Emilie A Chapeau; Agnieszka Gembarska; Eric Y Durand; Emeline Mandon; Claire Estadieu; Vincent Romanet; Marion Wiesmann; Ralph Tiedt; Joseph Lehar; Antoine de Weck; Roland Rad; Louise Barys; Sebastien Jeay; Stephane Ferretti; Audrey Kauffmann; Esther Sutter; Armelle Grevot; Pierre Moulin; Masato Murakami; William R Sellers; Francesco Hofmann; Michael Rugaard Jensen
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

Review 2.  Three decades of Wnts: a personal perspective on how a scientific field developed.

Authors:  Roel Nusse; Harold Varmus
Journal:  EMBO J       Date:  2012-05-22       Impact factor: 11.598

3.  Biological techniques: An embryonic view of tumour development.

Authors:  Pawel J Schweiger; Kim B Jensen
Journal:  Nature       Date:  2013-08-14       Impact factor: 49.962

Review 4.  Efficacy and safety of Sleeping Beauty transposon-mediated gene transfer in preclinical animal studies.

Authors:  Perry B Hackett; Elena L Aronovich; David Hunter; Myra Urness; Jason B Bell; Steven J Kass; Laurence J N Cooper; Scott McIvor
Journal:  Curr Gene Ther       Date:  2011-10       Impact factor: 4.391

5.  The Drosophila gene disruption project: progress using transposons with distinctive site specificities.

Authors:  Hugo J Bellen; Robert W Levis; Yuchun He; Joseph W Carlson; Martha Evans-Holm; Eunkyung Bae; Jaeseob Kim; Athanasios Metaxakis; Charalambos Savakis; Karen L Schulze; Roger A Hoskins; Allan C Spradling
Journal:  Genetics       Date:  2011-04-21       Impact factor: 4.562

Review 6.  Making sense of cancer genomic data.

Authors:  Lynda Chin; William C Hahn; Gad Getz; Matthew Meyerson
Journal:  Genes Dev       Date:  2011-03-15       Impact factor: 11.361

7.  Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Authors:  Michael B Mann; Michael A Black; Devin J Jones; Jerrold M Ward; Christopher Chin Kuan Yew; Justin Y Newberg; Adam J Dupuy; Alistair G Rust; Marcus W Bosenberg; Martin McMahon; Cristin G Print; Neal G Copeland; Nancy A Jenkins
Journal:  Nat Genet       Date:  2015-04-13       Impact factor: 38.330

Review 8.  Integration site selection by retroviruses and transposable elements in eukaryotes.

Authors:  Tania Sultana; Alessia Zamborlini; Gael Cristofari; Pascale Lesage
Journal:  Nat Rev Genet       Date:  2017-03-13       Impact factor: 53.242

9.  Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.

Authors:  Jian Zhong Tang; Catherine L Carmichael; Wei Shi; Donald Metcalf; Ashley P Ng; Craig D Hyland; Nancy A Jenkins; Neal G Copeland; Viive M Howell; Zhizhuang Joe Zhao; Gordon K Smyth; Benjamin T Kile; Warren S Alexander
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-26       Impact factor: 11.205

Review 10.  Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

Authors:  Barbara R Tschida; David A Largaespada; Vincent W Keng
Journal:  Semin Cell Dev Biol       Date:  2014-01-24       Impact factor: 7.727
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