| Literature DB >> 20843686 |
Olivier Corminboeuf1, Olivier Bezençon, Corinna Grisostomi, Luboš Remeň, Sylvia Richard-Bildstein, Daniel Bur, Lars Prade, Patrick Hess, Panja Strickner, Walter Fischli, Beat Steiner, Alexander Treiber.
Abstract
The discovery of a new series of piperidine-based renin inhibitors is described herein. SAR optimization upon the P3 renin sub-pocket is described, leading to the discovery of 9 and 41, two bioavailable renin inhibitors orally active at low doses in a transgenic rat model of hypertension.Entities:
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Year: 2010 PMID： 20843686 DOI： 10.1016/j.bmcl.2010.08.086
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823