BACKGROUND AND AIMS: In contrast to lipoprotein components, few studies have analysed the importance of a combination of commonly available inflammatory markers as predictors of major cardiovascular events (MACE) in large healthy populations. We examined summary scores of inflammation and compared their predictive strength with that of lipoproteins in the Apolipoprotein MOrtality RISk (AMORIS) Study. METHOD AND RESULTS: Using data from AMORIS and the Swedish hospital discharge and mortality registers, a prospective cohort study of 65,050 subjects with mean follow-up time of 11.8 years, we studied the association between lipoproteins, inflammatory markers and risk of acute myocardial infarction (AMI), stroke and heart failure. An inflammatory score was measured as the number of inflammatory variables (white blood cell count, haptoglobin and in a subgroup CRP) in their upper quartile or as a continuous summary score. All analyses were conducted with multivariate Cox proportional hazards analysis. The inflammatory scores added predictive information over and above classical lipids such as total cholesterol and triglycerides. Compared to the apolipoprotein B (apoB)/apolipoprotein A-1 (apoA-1) ratio, a stronger marker of CVD risk than conventional lipids, the inflammatory score added some discrimination value measured by net reclassification improvement, but added more within higher risk strata. No statistically significant biological interaction was found between lipoproteins and inflammatory markers. CONCLUSION: The inflammation score and lipoproteins, including apoB and apoA-I, carry important and at least additive predictive information for risk of MACE. Routinely used markers of inflammation could be used in daily medical practice to assess cardiovascular risk.
BACKGROUND AND AIMS: In contrast to lipoprotein components, few studies have analysed the importance of a combination of commonly available inflammatory markers as predictors of major cardiovascular events (MACE) in large healthy populations. We examined summary scores of inflammation and compared their predictive strength with that of lipoproteins in the Apolipoprotein MOrtality RISk (AMORIS) Study. METHOD AND RESULTS: Using data from AMORIS and the Swedish hospital discharge and mortality registers, a prospective cohort study of 65,050 subjects with mean follow-up time of 11.8 years, we studied the association between lipoproteins, inflammatory markers and risk of acute myocardial infarction (AMI), stroke and heart failure. An inflammatory score was measured as the number of inflammatory variables (white blood cell count, haptoglobin and in a subgroup CRP) in their upper quartile or as a continuous summary score. All analyses were conducted with multivariate Cox proportional hazards analysis. The inflammatory scores added predictive information over and above classical lipids such as total cholesterol and triglycerides. Compared to the apolipoprotein B (apoB)/apolipoprotein A-1 (apoA-1) ratio, a stronger marker of CVD risk than conventional lipids, the inflammatory score added some discrimination value measured by net reclassification improvement, but added more within higher risk strata. No statistically significant biological interaction was found between lipoproteins and inflammatory markers. CONCLUSION: The inflammation score and lipoproteins, including apoB and apoA-I, carry important and at least additive predictive information for risk of MACE. Routinely used markers of inflammation could be used in daily medical practice to assess cardiovascular risk.
Authors: Ji Young Huh; George Webster Ross; Randi Chen; Robert D Abbott; Christina Bell; Bradley Willcox; Lenore Launer; Helen Petrovitch; Brock Kaya; Kamal Masaki Journal: J Am Geriatr Soc Date: 2015-03-04 Impact factor: 5.562
Authors: Philippe Froguel; Ndeye Coumba Ndiaye; Amélie Bonnefond; Nabila Bouatia-Naji; Aurélie Dechaume; Gérard Siest; Bernard Herbeth; Mario Falchi; Leonardo Bottolo; Rosa-Maria Guéant-Rodriguez; Cécile Lecoeur; Michel R Langlois; Yann Labrune; Aimo Ruokonen; Said El Shamieh; Maria G Stathopoulou; Anita Morandi; Claudio Maffeis; David Meyre; Joris R Delanghe; Peter Jacobson; Lars Sjöström; Lena M S Carlsson; Andrew Walley; Paul Elliott; Marjo-Riita Jarvelin; George V Dedoussis; Sophie Visvikis-Siest Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240
Authors: Thomas J Degraba; Gerard T Hoehn; Paul A Nyquist; Honghui Wang; Ray Kenney; Denise A Gonzales; Steven J Kern; Sai-Xia Ying; Peter J Munson; Anthony F Suffredini Journal: Cerebrovasc Dis Extra Date: 2011-12-03
Authors: Wahyu Wulaningsih; Karl Michaelsson; Hans Garmo; Niklas Hammar; Ingmar Jungner; Göran Walldius; Mats Lambe; Lars Holmberg; Mieke Van Hemelrijck Journal: BMC Public Health Date: 2013-07-17 Impact factor: 3.295