Literature DB >> 208432

Maintenance of foals with combined immunodeficiency: causes and control of secondary infections.

L E Perryman, T C McGuire, T B Crawford.   

Abstract

Sixty-six cases of combined immunodeficiency (CID) in foals were studied to determine the most prevalent causes of infection and death. Lesions of the respiratory system were observed in 59 of the foals and were attributable to infection with equine adenovirus. Pneumocystis carinii, and bacteria. Significant lesions were also observed in liver, pancreas, intestines, heart, and kidneys. Maintenance of foals with CID for experimental purposes is directed at the prevention and control of these secondary infections. Adenovirus can be controlled by administration of horse plasma containing high titers of antiadenovirus antibody. Bacteria are controlled by appropriate antibiotic therapy. Pneumocystis carinii infection remains a significant problem in the maintenance of foals with CID.

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Year:  1978        PMID： 208432

Source DB:  PubMed          Journal:  Am J Vet Res        ISSN： 0002-9645            Impact factor:   1.156


  10 in total

1.  Immune reconstitution prevents continuous equine infectious anemia virus replication in an Arabian foal with severe combined immunodeficiency: lessons for control of lentiviruses.

Authors:  R H Mealey; D G Fraser; J L Oaks; G H Cantor; T C McGuire
Journal:  Clin Immunol       Date:  2001-11       Impact factor: 3.969

2.  Protective effects of passively transferred merozoite-specific antibodies against Theileria equi in horses with severe combined immunodeficiency.

Authors:  Robert H Mealey; Lowell S Kappmeyer; Massaro W Ueti; Bettina Wagner; Donald P Knowles
Journal:  Clin Vaccine Immunol       Date:  2011-10-28

3.  Selection of a rare neutralization-resistant variant following passive transfer of convalescent immune plasma in equine infectious anemia virus-challenged SCID horses.

Authors:  Sandra D Taylor; Steven R Leib; Susan Carpenter; Robert H Mealey
Journal:  J Virol       Date:  2010-04-14       Impact factor: 5.103

4.  A primary production deficit in the thrombocytopenia of equine infectious anemia.

Authors:  T B Crawford; K J Wardrop; S J Tornquist; E Reilich; K M Meyers; T C McGuire
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

5.  Infection of immunodeficient horses with Sarcocystis neurona does not result in neurologic disease.

Authors:  Debra C Sellon; Donald P Knowles; Ellis C Greiner; Maureen T Long; Melissa T Hines; Tressa Hochstatter; Ahmed Tibary; John B Dame
Journal:  Clin Diagn Lab Immunol       Date:  2004-11

6.  Specific immune responses are required to control parasitemia in Babesia equi infection.

Authors:  D P Knowles; L S Kappmeyer; L E Perryman
Journal:  Infect Immun       Date:  1994-05       Impact factor: 3.441

7.  In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency.

Authors:  N S Magnuson; L E Perryman
Journal:  J Clin Invest       Date:  1979-07       Impact factor: 14.808

8.  Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy.

Authors:  Robert H Mealey; Matt H Littke; Steven R Leib; William C Davis; Travis C McGuire
Journal:  Vet Immunol Immunopathol       Date:  2007-07-25       Impact factor: 2.046

9.  Pneumocystis carinii pneumonia in thoroughbred foals: identification of a genetically distinct organism by DNA amplification.

Authors:  S E Peters; A E Wakefield; K E Whitwell; J M Hopkin
Journal:  J Clin Microbiol       Date:  1994-01       Impact factor: 5.948

10.  Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.

Authors:  L E Perryman; K I O'Rourke; T C McGuire
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103
  10 in total

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