Literature DB >> 2084125

Determination of pholcodine and its metabolites in urine by capillary gas chromatography.

M Johansen1, K E Rasmussen, A S Christophersen.   

Abstract

A sensitive and selective method for the determination of pholcodine and its metabolites in urine using capillary gas chromatography with nitrogen detection is described. The procedure includes enzymatic hydrolysis of urine by beta-glucuronidase and sample pretreatment on C2 solid-phase extraction columns. Validation of the method showed good sensitivity, precision and reproducibility. The method was useful for the study of pholcodine metabolism in man. Pholcodine was found to conjugate with glucuronic acid. Morphine was identified as a metabolite and another unidentified metabolite was also detected.

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Year:  1990        PMID： 2084125     DOI： 10.1016/s0378-4347(00)83778-0

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

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Authors:  Edward J Cone; Marilyn A Huestis
Journal:  Ann N Y Acad Sci       Date:  2007-03-01       Impact factor: 5.691

2.  Instantaneous rigor after fatal pholcodine intoxication.

Authors:  Pierre Esnault; Bertrand Prunet; Guillaume Lacroix; Erwan D'Aranda; Yvan Gaillard; Henry Boret
Journal:  Br J Clin Pharmacol       Date:  2014-03       Impact factor: 4.335

3.  Paper-based potentiometric sensing devices modified with chemically reduced graphene oxide (CRGO) for trace level determination of pholcodine (opiate derivative drug).

Authors:  Hisham S M Abd-Rabboh; Abd El-Galil E Amr; Elsayed A Elsayed; Ahmed Y A Sayed; Ayman H Kamel
Journal:  RSC Adv       Date:  2021-03-26       Impact factor: 4.036

4.  Determination of pholcodine alone or in combination with ephedrine in human plasma using fluorescence spectroscopy.

Authors:  Heba Elmansi; Fathalla Belal; Galal Magdy
Journal:  Sci Rep       Date:  2022-06-07       Impact factor: 4.996
  4 in total

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