| Literature DB >> 2083978 |
Abstract
A radioimmunoassay employing cephalothin linked to a solid phase has been developed for the detection of cephalosporin-reactive IgE antibodies. Direct binding and inhibition studies demonstrated allergenic cross-reactivity between cephalosporins and penicillins, and quantitative hapten inhibition experiments identified the 2-thiophene group, and particularly the attached methylene group, of cephalothin as an allergenic determinant.Entities:
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Year: 1990 PMID： 2083978 DOI： 10.1159/000235177
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915