DVT prophylaxis: better living through chemistry: opposes.

The association between total hip arthroplasty and subsequent postoperative deep venous thrombosis is of particular concern because it can lead to symptomatic venous thromboembolic events. However, controversy remains about the optimal approach to prophylaxis. Some authors recommend the use of various chemoprophylactic agents, while others advocate the use of mechanical devices or combinations. The ideal method of prophylaxis should be effective and easy to administer, have a predictable onset and duration, have minimal interaction with food or other drugs, be easily reversible, be cost effective, and have a low risk of side effects. While available chemoprophylactic agents address some of these attributes, all have substantial drawbacks. Among the most concerning effects for orthopedic surgeons is the increased risk of bleeding and hematoma formation, which can be associated with periprosthetic infections. These typically lead to additional surgical procedures and significant patient morbidity, and can adversely impact clinical outcomes. An alternative to chemoprophylaxis is the use of pneumatic intermittent compression devices. Modern compression devices are portable and easy to use, and have a high rate of patient compliance. Several studies have demonstrated the efficacy of these devices in reducing the risk of symptomatic venous thromboembolic disease, in some cases resulting in lower mortality when compared to pharmacological agents. Additionally, these devices significantly reduce the risk of postoperative bleeding. Copyright 2010, SLACK Incorporated.