Literature DB >> 20837152

Wnt signaling in stem and cancer stem cells.

Peter Wend1, Jane D Holland, Ulrike Ziebold, Walter Birchmeier.   

Abstract

Canonical Wnt signaling supports the formation and maintenance of stem and cancer stem cells. Recent studies have elucidated epigenetic mechanisms that control pluripotency and stemness, and allow a first assessment how embryonic and tissue stem cells are generated and maintained, and how Wnt signaling might be involved. The core of this review highlights the roles of Wnt signaling in stem and cancer stem cells of tissues such as skin, intestine and mammary gland. Lastly, we refer to the characterization of novel and powerful inhibitors of canonical Wnt signaling and describe attempts to bring these compounds into preclinical and clinical studies.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20837152     DOI： 10.1016/j.semcdb.2010.09.004

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  99 in total

1.  Expression of Wnt9, TCTP, and Bmp1/Tll in sea cucumber visceral regeneration.

Authors:  Vladimir S Mashanov; Olga R Zueva; Jose E Garcia-Arraras
Journal:  Gene Expr Patterns       Date:  2011-11-04       Impact factor: 1.224

Review 2.  Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.

Authors:  Caroline M Alexander; Shruti Goel; Saja A Fakhraldeen; Soyoung Kim
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-10-01       Impact factor: 10.005

Review 3.  EpCAM and its potential role in tumor-initiating cells.

Authors:  Sannia Imrich; Matthias Hachmeister; Olivier Gires
Journal:  Cell Adh Migr       Date:  2012 Jan-Feb       Impact factor: 3.405

Review 4.  Phosphoproteomic analysis: an emerging role in deciphering cellular signaling in human embryonic stem cells and their differentiated derivatives.

Authors:  Brian T D Tobe; Junjie Hou; Andrew M Crain; Ilyas Singec; Evan Y Snyder; Laurence M Brill
Journal:  Stem Cell Rev Rep       Date:  2012-03       Impact factor: 5.739

Review 5.  Targeting MET in cancer: rationale and progress.

Authors:  Ermanno Gherardi; Walter Birchmeier; Carmen Birchmeier; George Vande Woude
Journal:  Nat Rev Cancer       Date:  2012-01-24       Impact factor: 60.716

Review 6.  Wnt signaling and the control of human stem cell fate.

Authors:  J K Van Camp; S Beckers; D Zegers; W Van Hul
Journal:  Stem Cell Rev Rep       Date:  2014-04       Impact factor: 5.739

Review 7.  Epithelial-to-mesenchymal transition in thyroid cancer: a comprehensive review.

Authors:  Heewa Shakib; Sadegh Rajabi; Mohammad Hossien Dehghan; Farideh Jalali Mashayekhi; Nahid Safari-Alighiarloo; Mehdi Hedayati
Journal:  Endocrine       Date:  2019-08-04       Impact factor: 3.633

Review 8.  Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this?

Authors:  Qian Zhang; Yunjiang Feng; Derek Kennedy
Journal:  Cell Mol Life Sci       Date:  2016-09-12       Impact factor: 9.261

Review 9.  Mammary gland development.

Authors:  Hector Macias; Lindsay Hinck
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2012 Jul-Aug       Impact factor: 5.814

10.  Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974.

Authors:  Jonathan D Boone; Rebecca C Arend; Bobbi E Johnston; Sara J Cooper; Scott A Gilchrist; Denise K Oelschlager; William E Grizzle; Gerald McGwin; Abhishek Gangrade; J Michael Straughn; Donald J Buchsbaum
Journal:  Lab Invest       Date:  2015-12-14       Impact factor: 5.662
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