Literature DB >> 20836515

An optimized immunoaffinity fluorescent method for natural product target elucidation.

Wei-Luen Yu1, Gianni Guizzunti, Timothy L Foley, Michael D Burkart, James J La Clair.   

Abstract

Understanding the mode of action of small molecules is an integral facet of drug discovery. We report an optimized immunoaffinity fluorescent method that allows one to conduct parallel studies at both the cellular and molecular level using a single probe construct. Viability of the method has been evaluated analytically and applied using glycyrrhetic acid as a model.

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Year:  2010        PMID： 20836515     DOI： 10.1021/np100371k

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  15 in total

1.  Irreversible Protein Labeling by Paal-Knorr Conjugation.

Authors:  Ramesh Dasari; James J La Clair; Alexander Kornienko
Journal:  Chembiochem       Date:  2017-08-10       Impact factor: 3.164

2.  Fluorescent Mechanism-Based Probe for Aerobic Flavin-Dependent Enzyme Activity.

Authors:  Ian P McCulloch; James J La Clair; Matt J Jaremko; Michael D Burkart
Journal:  Chembiochem       Date:  2016-08-05       Impact factor: 3.164

3.  Synthesis and evaluation of a fluorescent ritterazine-cephalostatin hybrid.

Authors:  Kanduluru Ananda Kumar; James J La Clair; Philip L Fuchs
Journal:  Org Lett       Date:  2011-09-14       Impact factor: 6.005

4.  Brusatol overcomes chemoresistance through inhibition of protein translation.

Authors:  Bryan Harder; Wang Tian; James J La Clair; Aik-Choon Tan; Aikseng Ooi; Eli Chapman; Donna D Zhang
Journal:  Mol Carcinog       Date:  2017-02-08       Impact factor: 4.784

5.  Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).

Authors:  Wei-Lun Yu; Brian D Jones; Minjin Kang; Justin C Hammons; James J La Clair; Michael D Burkart
Journal:  J Nat Prod       Date:  2013-05-09       Impact factor: 4.050

6.  Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78.

Authors:  Andrew J Ambrose; Evelyne A Santos; Paula C Jimenez; Danilo D Rocha; Diego V Wilke; Paolo Beuzer; Josh Axelrod; Ananda Kumar Kanduluru; Philip L Fuchs; Hu Cang; Letícia V Costa-Lotufo; Eli Chapman; James J La Clair
Journal:  Chembiochem       Date:  2017-02-02       Impact factor: 3.164

7.  Dehydratase-specific probes for fatty acid and polyketide synthases.

Authors:  Fumihiro Ishikawa; Robert W Haushalter; Michael D Burkart
Journal:  J Am Chem Soc       Date:  2011-12-29       Impact factor: 15.419

8.  Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.

Authors:  Lynnie Trzoss; Takashi Fukuda; Letícia V Costa-Lotufo; Paula Jimenez; James J La Clair; William Fenical
Journal:  Proc Natl Acad Sci U S A       Date:  2014-09-30       Impact factor: 11.205

9.  Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94.

Authors:  Lauge Farnaes; James J La Clair; William Fenical
Journal:  Org Biomol Chem       Date:  2013-11-29       Impact factor: 3.876

10.  Color-Coded Super-Resolution Small-Molecule Imaging.

Authors:  Paolo Beuzer; James J La Clair; Hu Cang
Journal:  Chembiochem       Date:  2016-04-26       Impact factor: 3.164
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