| Literature DB >> 20836033 |
Gregg L Semenza1,2,3.
Abstract
Metazoan life is dependent upon the utilization of O(2) for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.Entities:
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Year: 2010 PMID： 20836033 DOI： 10.1002/wsbm.69
Source DB: PubMed Journal: Wiley Interdiscip Rev Syst Biol Med ISSN： 1939-005X