OBJECTIVES: To address the recent hypothesis that hypertension increases the risk of death from external causes. METHODS: We examined blood pressure and death from external causes among 82,037 male physicians who were screened for eligibility to enroll in the Physicians' Health Study. RESULTS: During up to 6.6 years of mortality follow-up, there were 304 deaths from external causes. No association was found overall, although we observed an increased risk of non-passive external causes of death, particularly death due to falls, which was independent of various lifestyle, medical, and pharmacological risk factors. CONCLUSIONS: The results of our study support this novel hypothesis. Further studies are needed to explore potential causal mechanisms between elevated BP and the risk of external death.
RCT Entities:
OBJECTIVES: To address the recent hypothesis that hypertension increases the risk of death from external causes. METHODS: We examined blood pressure and death from external causes among 82,037 male physicians who were screened for eligibility to enroll in the Physicians' Health Study. RESULTS: During up to 6.6 years of mortality follow-up, there were 304 deaths from external causes. No association was found overall, although we observed an increased risk of non-passive external causes of death, particularly death due to falls, which was independent of various lifestyle, medical, and pharmacological risk factors. CONCLUSIONS: The results of our study support this novel hypothesis. Further studies are needed to explore potential causal mechanisms between elevated BP and the risk of external death.
Authors: J M Starr; S A Leaper; A D Murray; H A Lemmon; R T Staff; I J Deary; L J Whalley Journal: J Neurol Neurosurg Psychiatry Date: 2003-01 Impact factor: 10.154
Authors: Aram V Chobanian; George L Bakris; Henry R Black; William C Cushman; Lee A Green; Joseph L Izzo; Daniel W Jones; Barry J Materson; Suzanne Oparil; Jackson T Wright; Edward J Roccella Journal: JAMA Date: 2003-05-14 Impact factor: 56.272
Authors: Cristina Sierra; Alejandro De La Sierra; Manel Salamero; Javier Sobrino; Elisenda Gómez-Angelats; Antonio Coca Journal: Am J Hypertens Date: 2004-06 Impact factor: 2.689
Authors: C H Hennekens; J E Buring; J E Manson; M Stampfer; B Rosner; N R Cook; C Belanger; F LaMotte; J M Gaziano; P M Ridker; W Willett; R Peto Journal: N Engl J Med Date: 1996-05-02 Impact factor: 91.245