Literature DB >> 20835425

α,α'-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes.

James L Galman1, David Steadman, Sarah Bacon, Phattaraporn Morris, Mark E B Smith, John M Ward, Paul A Dalby, Helen C Hailes.   

Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

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Year:  2010        PMID： 20835425     DOI： 10.1039/c0cc02911d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Directed evolution to re-adapt a co-evolved network within an enzyme.

Authors:  John Strafford; Panwajee Payongsri; Edward G Hibbert; Phattaraporn Morris; Sukhjeet S Batth; David Steadman; Mark E B Smith; John M Ward; Helen C Hailes; Paul A Dalby
Journal:  J Biotechnol       Date:  2011-11-29       Impact factor: 3.307

2.  Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes.

Authors:  Pierre E Affaticati; Shao-Bo Dai; Panwajee Payongsri; Helen C Hailes; Kai Tittmann; Paul A Dalby
Journal:  Sci Rep       Date:  2016-10-21       Impact factor: 4.379

3.  Two strategies to engineer flexible loops for improved enzyme thermostability.

Authors:  Haoran Yu; Yihan Yan; Cheng Zhang; Paul A Dalby
Journal:  Sci Rep       Date:  2017-02-01       Impact factor: 4.379

4.  Separating Thermodynamics from Kinetics-A New Understanding of the Transketolase Reaction.

Authors:  Stefan R Marsden; Lorina Gjonaj; Stephen J Eustace; Ulf Hanefeld
Journal:  ChemCatChem       Date:  2017-04-13       Impact factor: 5.686

5.  Biophysical characterization of the inactivation of E. coli transketolase by aqueous co-solvents.

Authors:  Phattaraporn Morris; Ribia García-Arrazola; Leonardo Rios-Solis; Paul A Dalby
Journal:  Sci Rep       Date:  2021-12-08       Impact factor: 4.379

6.  Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis.

Authors:  Max Cárdenas-Fernández; Fabiana Subrizi; Dragana Dobrijevic; Helen C Hailes; John M Ward
Journal:  Org Biomol Chem       Date:  2021-07-28       Impact factor: 3.876
  6 in total

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