INTRODUCTION: To determine the relationship between fibrin D-dimer levels, symptom duration, and thrombus volume, consecutive patients with incident deep venous thrombosis (DVT) were evaluated. METHODS: In a cross-sectional study design, patient symptom onset was determined by careful patient questioning. Venous thrombosis was confirmed by compression duplex ultrasonography. Thrombus volume was estimated based on patient's femur length using a forensic anthropology method. Fibrin D-dimer was measured by latex immunoassay. RESULTS: 72 consecutive patients with confirmed leg DVT agreed to participate. The median symptom duration at the time of diagnosis was 10 days. The median D-dimer concentration was 1050 ng/dL. The median thrombus volume was 12.92 cm(3). D-Dimer levels correlated with estimated thrombus volume (P < .0006 CI 0.12-0.41; R(2) (adjusted) = .15) but not symptom duration, patient's age, or gender. CONCLUSIONS: Despite varying symptom duration prior to diagnosis, fibrin D-dimer remains a sensitive measure of venous thrombosis and correlates with thrombus volume.
INTRODUCTION: To determine the relationship between fibrin D-dimer levels, symptom duration, and thrombus volume, consecutive patients with incident deep venous thrombosis (DVT) were evaluated. METHODS: In a cross-sectional study design, patient symptom onset was determined by careful patient questioning. Venous thrombosis was confirmed by compression duplex ultrasonography. Thrombus volume was estimated based on patient's femur length using a forensic anthropology method. Fibrin D-dimer was measured by latex immunoassay. RESULTS: 72 consecutive patients with confirmed leg DVT agreed to participate. The median symptom duration at the time of diagnosis was 10 days. The median D-dimer concentration was 1050 ng/dL. The median thrombus volume was 12.92 cm(3). D-Dimer levels correlated with estimated thrombus volume (P < .0006 CI 0.12-0.41; R(2) (adjusted) = .15) but not symptom duration, patient's age, or gender. CONCLUSIONS: Despite varying symptom duration prior to diagnosis, fibrin D-dimer remains a sensitive measure of venous thrombosis and correlates with thrombus volume.
Authors: Albeir Y Mousa; Mike Broce; David De Wit; Mina Baskharoun; Shadi Abu-Halimah; Michael Yacoub; Mark C Bates Journal: Ann Vasc Surg Date: 2018-03-01 Impact factor: 1.466
Authors: Albeir Y Mousa; Mike Broce; Gurpreet Gill; Maher Kali; Michael Yacoub; Ali F AbuRahma Journal: Ann Vasc Surg Date: 2014-10-05 Impact factor: 1.466
Authors: Benjamin E Levy; Md Murad Hossain; Justin M Sierchio; Diwash Thapa; Caterina M Gallippi; Amy L Oldenburg Journal: IEEE Trans Ultrason Ferroelectr Freq Control Date: 2018-05-28 Impact factor: 2.725