Literature DB >> 20833358

pRb, a switch between bone and brown fat.

Pablo J Fernandez-Marcos1, Johan Auwerx.   

Abstract

Calo et al. (2010) recently reported that the absence of the transcriptional regulator pRb enhances differentiation of mesenchymal precursors toward the brown adipocyte lineage in detriment of osteoblast and white fat populations. These findings may have therapeutic implications for cancer and bone and metabolic disease.
Copyright © 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20833358      PMCID： PMC3615535          DOI： 10.1016/j.devcel.2010.08.018

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

1.  The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.

Authors:  D M Thomas; S A Carty; D M Piscopo; J S Lee; W F Wang; W C Forrester; P W Hinds
Journal:  Mol Cell       Date:  2001-08       Impact factor: 17.970

2.  The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation.

Authors:  Lluis Fajas; Viviane Egler; Raphael Reiter; Jacob Hansen; Karsten Kristiansen; Marie-Bernard Debril; Stéphanie Miard; Johan Auwerx
Journal:  Dev Cell       Date:  2002-12       Impact factor: 12.270

Review 3.  E2F-Rb complexes regulating transcription of genes important for differentiation and development.

Authors:  Michael Korenjak; Alexander Brehm
Journal:  Curr Opin Genet Dev       Date:  2005-10       Impact factor: 5.578

Review 4.  Transcriptional control of brown fat development.

Authors:  Shingo Kajimura; Patrick Seale; Bruce M Spiegelman
Journal:  Cell Metab       Date:  2010-04-07       Impact factor: 27.287

5.  A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

Authors:  Marta Puyol; Alberto Martín; Pierre Dubus; Francisca Mulero; Pilar Pizcueta; Gulfaraz Khan; Carmen Guerra; David Santamaría; Mariano Barbacid
Journal:  Cancer Cell       Date:  2010-07-13       Impact factor: 31.743

6.  The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development.

Authors:  Seth D Berman; Tina L Yuan; Emily S Miller; Eunice Y Lee; Alicia Caron; Jacqueline A Lees
Journal:  Mol Cancer Res       Date:  2008-09       Impact factor: 5.852

7.  Rb regulates fate choice and lineage commitment in vivo.

Authors:  Eliezer Calo; Jose A Quintero-Estades; Paul S Danielian; Simona Nedelcu; Seth D Berman; Jacqueline A Lees
Journal:  Nature       Date:  2010-08-04       Impact factor: 49.962

8.  E2Fs regulate adipocyte differentiation.

Authors:  Lluis Fajas; Rebecca L Landsberg; Yolande Huss-Garcia; Claude Sardet; Jacqueline A Lees; Johan Auwerx
Journal:  Dev Cell       Date:  2002-07       Impact factor: 12.270

9.  Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.

Authors:  Nassim Dali-Youcef; Chikage Mataki; Agnès Coste; Nadia Messaddeq; Sylvain Giroud; Stéphane Blanc; Christian Koehl; Marie-France Champy; Pierre Chambon; Lluis Fajas; Daniel Metzger; Kristina Schoonjans; Johan Auwerx
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-07       Impact factor: 11.205

10.  Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

Authors:  Jacob B Hansen; Claus Jørgensen; Rasmus K Petersen; Philip Hallenborg; Rita De Matteis; Hans A Bøye; Natasa Petrovic; Sven Enerbäck; Jan Nedergaard; Saverio Cinti; Hein te Riele; Karsten Kristiansen
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205
  10 in total
  2 in total

1.  Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes.

Authors:  A Krings; S Rahman; S Huang; Y Lu; P J Czernik; B Lecka-Czernik
Journal:  Bone       Date:  2011-06-24       Impact factor: 4.398

2.  Association between brown adipose tissue and bone mineral density in humans.

Authors:  Guillermo Sanchez-Delgado; Borja Martinez-Tellez; Yolanda Garcia-Rivero; Francisco M Acosta; Juan M A Alcantara; Francisco J Amaro-Gahete; Jose M Llamas-Elvira; Luis Gracia-Marco; Jonatan R Ruiz
Journal:  Int J Obes (Lond)       Date:  2018-12-05       Impact factor: 5.095
  2 in total

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