| Literature DB >> 20833264 |
Paul T Henderson1, Mark D Evans, Marcus S Cooke.
Abstract
Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools. 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID: 20833264 PMCID: PMC2991500 DOI: 10.1016/j.mrgentox.2010.08.021
Source DB: PubMed Journal: Mutat Res ISSN: 0027-5107 Impact factor: 2.433