Literature DB >> 20833149

Marine natural products targeting phospholipases A2.

Florence Folmer1, Marcel Jaspars, Marc Schumacher, Mario Dicato, Marc Diederich.   

Abstract

Phospholipases A(2) (PLA(2)s) form a family of enzymes catalyzing the hydrolysis of membrane phospholipids into arachidonic acid, which is the major precursor of pro-inflammatory eicosanoids. As a result, PLA(2)s have been considered as potential targets in anti-inflammatory drug discovery. Marine natural products are a rich source of bioactive compounds, including PLA(2) inhibitors. Here, we review the properties of marine PLA(2) inhibitors identified since the first discovery of PLA(2) inhibitory activity in the marine natural product manoalide in the mid 1980s.
Copyright © 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20833149     DOI： 10.1016/j.bcp.2010.08.024

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  13 in total

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