| Literature DB >> 20833042 |
Stephen P O'Connor1, Ying Wang, Ligaya M Simpkins, Robert P Brigance, Wei Meng, Aiying Wang, Mark S Kirby, Carolyn A Weigelt, Lawrence G Hamann.
Abstract
The synthesis and SAR of aminomethyl-substituted imidazolopyrimidine DPP4 inhibitors bearing varied pendant aryl groups is described. Compound 1, which exists as a separable mixture of non-interconvertible atropisomers was used as the starting point for investigation. The effects of substituent pattern and type as well as stereochemical effects on inhibitor potency are discussed.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20833042 DOI： 10.1016/j.bmcl.2010.08.090
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823