| Literature DB >> 20831266 |
Yaguang Bai1, Jing Zeng, Jimei Ma, Bala Kishan Gorityala, Xue-Wei Liu.
Abstract
A direct and efficient approach to 1-aminoindolizines through three-component one-pot reaction of heteroaryl aldehydes, secondary amines, and terminal alkynes catalyzed by AgBF(4) has been developed. Desired products were obtained in moderate to excellent yields. Similar aminoindolizines products were afforded from trimethylsilyl protected alkyne substrates as well. This methodology provides a rapid access to construct a diversity-oriented library of indolizines.Entities:
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Year: 2010 PMID： 20831266 DOI： 10.1021/cc100086h
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766