| Literature DB >> 20831195 |
Hui-Wen Shih1, Mark N Vander Wal, Rebecca L Grange, David W C MacMillan.
Abstract
The first enantioselective aldehyde α-benzylation using electron-deficient aryl and heteroaryl substrates has been accomplished. The productive merger of a chiral imidazolidinone organocatalyst and a commercially available iridium photoredox catalyst in the presence of household fluorescent light directly affords the desired homobenzylic stereogenicity in good to excellent yield and enantioselectivity. The utility of this methodology has been demonstrated via rapid access to an enantioenriched drug target for angiogenesis suppression.Entities:
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Year: 2010 PMID： 20831195 PMCID： PMC3056320 DOI： 10.1021/ja106593m
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419