Literature DB >> 20830433

A turn-on split-luciferase sensor for the direct detection of poly(ADP-ribose) as a marker for DNA repair and cell death.

Jennifer L Furman1, Pui-Wing Mok, Shengyi Shen, Cliff I Stains, Indraneel Ghosh.   

Abstract

Designed sensors comprising split-firefly luciferase conjugated to tandem poly(ADP-ribose) binding domains allow for the direct solution phase detection of picogram quantities of PAR and for monitoring temporal changes in poly(ADP-ribosyl)ation events in mammalian cells.

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Year:  2010        PMID： 20830433     DOI： 10.1039/c0cc02229b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

Review 1.  Split-protein systems: beyond binary protein-protein interactions.

Authors:  Sujan S Shekhawat; Indraneel Ghosh
Journal:  Curr Opin Chem Biol       Date:  2011-11-07       Impact factor: 8.822

2.  Turn-on DNA damage sensors for the direct detection of 8-oxoguanine and photoproducts in native DNA.

Authors:  Jennifer L Furman; Pui-Wing Mok; Ahmed H Badran; Indraneel Ghosh
Journal:  J Am Chem Soc       Date:  2011-05-17       Impact factor: 15.419

3.  Development and characterization of new tools for detecting poly(ADP-ribose) in vitro and in vivo.

Authors:  Sridevi Challa; Keun W Ryu; Amy L Whitaker; Jonathan C Abshier; Cristel V Camacho; W Lee Kraus
Journal:  Elife       Date:  2022-04-27       Impact factor: 8.713

4.  Live Cell Detection of Poly(ADP-Ribose) for Use in Genetic and Genotoxic Compound Screens.

Authors:  Christopher A Koczor; Aaron J Haider; Kate M Saville; Jianfeng Li; Joel F Andrews; Alison V Beiser; Robert W Sobol
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575

5.  Genetically Encoded Fluorescent Sensor for Poly-ADP-Ribose.

Authors:  Ekaterina O Serebrovskaya; Nadezda M Podvalnaya; Varvara V Dudenkova; Anna S Efremova; Nadya G Gurskaya; Dmitry A Gorbachev; Artem V Luzhin; Omar L Kantidze; Elena V Zagaynova; Stanislav I Shram; Konstantin A Lukyanov
Journal:  Int J Mol Sci       Date:  2020-07-15       Impact factor: 5.923
  5 in total

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