Literature DB >> 20830431

Mycobacterium tuberculosis tyrosine phosphatase A (PtpA) activity is modulated by S-nitrosylation.

Gabriela Ecco1, Javier Vernal, Guilherme Razzera, Priscila Alves Martins, Camila Matiollo, Hernán Terenzi.   

Abstract

M. tuberculosis PtpA and PtpB, the only two phosphotyrosine phosphatases (Ptps) present in this pathogen, play an important role in mycobacteria survival inside macrophages. The aim of the present work was to investigate M. tuberculosis PtpA and PtpB susceptibility to S-nitrosylation, a reversible covalent bond between nitric oxide (NO) and specific cysteine (sulfur) residues in proteins. PtpB was not modified by NO, in contrast, PtpA Cys53 was identified by site directed mutagenesis as the target of S-nitrosylation.

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Year:  2010        PMID： 20830431     DOI： 10.1039/c0cc01704c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Systematic Analysis of Mycobacterial Acylation Reveals First Example of Acylation-mediated Regulation of Enzyme Activity of a Bacterial Phosphatase.

Authors:  Anshika Singhal; Gunjan Arora; Richa Virmani; Parijat Kundu; Tanya Khanna; Andaleeb Sajid; Richa Misra; Jayadev Joshi; Vikas Yadav; Sintu Samanta; Neeru Saini; Amit K Pandey; Sandhya S Visweswariah; Christian Hentschker; Dörte Becher; Ulf Gerth; Yogendra Singh
Journal:  J Biol Chem       Date:  2015-09-08       Impact factor: 5.157

2.  Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase.

Authors:  Ritu Chakravarti; Dennis J Stuehr
Journal:  J Biol Chem       Date:  2012-03-28       Impact factor: 5.157

Review 3.  Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity.

Authors:  Petr Heneberg
Journal:  Antioxid Redox Signal       Date:  2014-03-11       Impact factor: 8.401

4.  Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products.

Authors:  Alessandra Mascarello; Mattia Mori; Louise Domeneghini Chiaradia-Delatorre; Angela Camila Orbem Menegatti; Franco Delle Monache; Franco Ferrari; Rosendo Augusto Yunes; Ricardo José Nunes; Hernán Terenzi; Bruno Botta; Maurizio Botta
Journal:  PLoS One       Date:  2013-10-14       Impact factor: 3.240

5.  Alterporriol-type dimers from the mangrove endophytic fungus, Alternaria sp. (SK11), and their MptpB inhibitions.

Authors:  Guoping Xia; Jia Li; Hanxiang Li; Yuhua Long; Shao'e Lin; Yongjun Lu; Lei He; Yongcheng Lin; Lan Liu; Zhigang She
Journal:  Mar Drugs       Date:  2014-05-16       Impact factor: 5.118

6.  Asperlones A and B, dinaphthalenone derivatives from a mangrove endophytic fungus Aspergillus sp. 16-5C.

Authors:  Ze'en Xiao; Shao'e Lin; Chunbing Tan; Yongjun Lu; Lei He; Xishan Huang; Zhigang She
Journal:  Mar Drugs       Date:  2015-01-13       Impact factor: 5.118

7.  Genetic-and-Epigenetic Interspecies Networks for Cross-Talk Mechanisms in Human Macrophages and Dendritic Cells during MTB Infection.

Authors:  Cheng-Wei Li; Yun-Lin Lee; Bor-Sen Chen
Journal:  Front Cell Infect Microbiol       Date:  2016-10-18       Impact factor: 5.293

8.  Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress.

Authors:  Melanie Hillion; Jörg Bernhardt; Tobias Busche; Martina Rossius; Sandra Maaß; Dörte Becher; Mamta Rawat; Markus Wirtz; Rüdiger Hell; Christian Rückert; Jörn Kalinowski; Haike Antelmann
Journal:  Sci Rep       Date:  2017-04-26       Impact factor: 4.379

9.  A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases.

Authors:  Jean B Bertoldo; Tiago Rodrigues; Lavinia Dunsmore; Francesco A Aprile; Marta C Marques; Leonardo A Rosado; Omar Boutureira; Thomas B Steinbrecher; Woody Sherman; Francisco Corzana; Hernán Terenzi; Gonçalo J L Bernardes
Journal:  Chem       Date:  2017-10-12       Impact factor: 22.804
  9 in total

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