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Literature DB >> 20830354

Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: gradual release enhances activity.

Anthony S Breitbach¹, Adam H Broderick, Christopher M Jewell, Suvai Gunasekaran, Qi Lin, David M Lynn, Helen E Blackwell.

Abstract

We demonstrate an approach to the surface-mediated release of a synthetic N-acylated L-homoserine lactone (AHL) modulator of bacterial quorum sensing (QS). AHL released gradually from thin films of poly(lactide-co-glycolide) (PLG) is shown to activate QS in the model symbiont Vibrio fischeri at levels that exceed those promoted by direct solution-based administration.

Entities: Chemical Disease Species

Mesh：

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Year: 2010 PMID： 20830354 PMCID： PMC3565574 DOI： 10.1039/c0cc02316g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

25 in total

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Review 3. Anti-virulence strategies to combat bacteria-mediated disease.

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Review 4. Reducing implant-related infections: active release strategies.

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Review 5. Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.

Authors: C Fuqua; M R Parsek; E P Greenberg
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6. N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa.

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7. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres.

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Review 8. Cell-cell communication in Gram-negative bacteria.

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10. Synthesis and stability of small molecule probes for Pseudomonas aeruginosa quorum sensing modulation.

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14 in total

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2. Physicochemical regulation of biofilm formation.

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Review 3. Chemical probes of quorum sensing: from compound development to biological discovery.

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4. Thiolactone modulators of quorum sensing revealed through library design and screening.

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5. Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing.

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6. 2-Aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms.

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7. Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control.

Authors: Michael J Kratochvil; Tian Yang; Helen E Blackwell; David M Lynn
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8. Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells.

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9. Surface-mediated release of a small-molecule modulator of bacterial biofilm formation: a non-bactericidal approach to inhibiting biofilm formation in Pseudomonas aeruginosa.

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10. Chemical methods to interrogate bacterial quorum sensing pathways.

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Journal: Org Biomol Chem Date: 2012-10-03 Impact factor: 3.876