| Literature DB >> 20828815 |
Ioana Borze1, Mohamed Guled, Suad Musse, Anna Raunio, Erkki Elonen, Ulla Saarinen-Pihkala, Marja-Liisa Karjalainen-Lindsberg, Leo Lahti, Sakari Knuutila.
Abstract
Due to availability of bone marrow core biopsies (CB) in many pathology laboratories, we evaluated the quality and the biological information of the miRNA profiling using 9 acute lymphoblastic leukemia (ALL) and 9 chronic myeloid leukemia (CML) matched CB and bone marrow aspirates (BA). Technical replicates showed reproducible results across platforms and clustered together in hierarchical clustering analysis; and matched samples showed similar biological content having common differentially expressed miRNAs against the same control samples. We showed, that CBs, which have underwent decalcification in addition to formalin-fixation, are suitable for miRNA profiling.Entities:
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Year: 2010 PMID: 20828815 DOI: 10.1016/j.leukres.2010.08.005
Source DB: PubMed Journal: Leuk Res ISSN: 0145-2126 Impact factor: 3.156