OBJECTIVE: To determine the gestational age (GA)-specific risks for neonatal morbidity and use of interventions in infants born at 30 to 34 completed gestational weeks. STUDY DESIGN: A population-based Swedish study including 6674 infants born during 2004-2008. Risks for neonatal morbidity and use of interventions were investigated with respect to GA and birth weight standard deviation scores. RESULTS: Acute lung disorder was diagnosed in 28%, hypoglycemia in 16%, bacterial infection in 15% and hyperbilirubinemia in 59% of the infants. Thirty-eight percent had received antenatal steroid therapy, 43% nasal continuous positive airway pressure, 5.5% required mechanical ventilation, 5.2% were treated with surfactant, and 30% with antibiotic therapy. Neonatal morbidity rates increased with decreasing GA, with odds ratios for different outcomes ranging from 2.1 to 23 at 30 weeks compared with 34 weeks of GA. Low birth weight standard deviation scores was more common at lower GA and was associated with increased morbidity rates. CONCLUSIONS: Despite general advances in perinatal care, moderately preterm infants still have substantially increased risks for neonatal morbidity. Whereas the neonatal morbidity rate was similar to results of previous reports, management of respiratory problems differed markedly from other studies.
OBJECTIVE: To determine the gestational age (GA)-specific risks for neonatal morbidity and use of interventions in infants born at 30 to 34 completed gestational weeks. STUDY DESIGN: A population-based Swedish study including 6674 infants born during 2004-2008. Risks for neonatal morbidity and use of interventions were investigated with respect to GA and birth weight standard deviation scores. RESULTS:Acute lung disorder was diagnosed in 28%, hypoglycemia in 16%, bacterial infection in 15% and hyperbilirubinemia in 59% of the infants. Thirty-eight percent had received antenatal steroid therapy, 43% nasal continuous positive airway pressure, 5.5% required mechanical ventilation, 5.2% were treated with surfactant, and 30% with antibiotic therapy. Neonatal morbidity rates increased with decreasing GA, with odds ratios for different outcomes ranging from 2.1 to 23 at 30 weeks compared with 34 weeks of GA. Low birth weight standard deviation scores was more common at lower GA and was associated with increased morbidity rates. CONCLUSIONS: Despite general advances in perinatal care, moderately preterm infants still have substantially increased risks for neonatal morbidity. Whereas the neonatal morbidity rate was similar to results of previous reports, management of respiratory problems differed markedly from other studies.
Authors: Sanjay Chawla; Girija Natarajan; Dhuly Chowdhury; Abhik Das; Michele Walsh; Edward F Bell; Abbot R Laptook; Krisa Van Meurs; Carl T D'Angio; Barbara J Stoll; Sara B DeMauro; Seetha Shankaran Journal: Am J Perinatol Date: 2018-04-27 Impact factor: 1.862
Authors: Girija Natarajan; Seetha Shankaran; Shampa Saha; Abbot Laptook; Abhik Das; Rosemary Higgins; Barbara J Stoll; Edward F Bell; Waldemar A Carlo; Carl D'Angio; Sara B DeMauro; Pablo Sanchez; Krisa Van Meurs; Betty Vohr; Nancy Newman; Ellen Hale; Michele Walsh Journal: J Pediatr Date: 2018-02-01 Impact factor: 4.406
Authors: Mohamed H Ibrahim; Ahmed A Azab; Naglaa M Kamal; Mostafa A Salama; Hatem H Elshorbagy; Enas A A Abdallah; Abdulrahman Hammad; Laila M Sherief Journal: Medicine (Baltimore) Date: 2015-06 Impact factor: 1.889
Authors: Georgina A V Murphy; Donald Waters; Paul O Ouma; David Gathara; Sasha Shepperd; Robert W Snow; Mike English Journal: BMJ Glob Health Date: 2017-11-14