Jost B Jonas1, Liang Xu, Xi Wei Xie, Ya Xing Wang. 1. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.
Abstract
PURPOSE: The purpose of this study was to assess the relationship between the fasting plasma glucose cutoff of 7 mmol/L and the presence of retinopathy in a population in China. METHODS: The Beijing Eye Study 2006 is a population-based study, which included 3,251 subjects aged >or= 45 years. By using fundus photographs, retinopathy was assessed according to the Early Treatment of Diabetic Retinopathy Study. RESULTS: The correlation between fasting plasma glucose concentration and retinopathy suggested a continuous relation instead of a uniform glycemic threshold for prevalent retinopathy. For the diabetes plasma glucose concentration cutoffs of 7.0 mmol/L, 5.6 mmol/L, and 7.8 mmol/L to differentiate between subjects with or without retinopathy, the sensitivities were 18.8%, 44.0%, and 15.4%, respectively, and the specificities were 94.3%, 73.8%, and 96.6%, respectively. After excluding subjects with known diabetes and/or subjects on antidiabetic treatment, the sensitivities of diabetes plasma glucose concentration cutoffs of 7.0 mmol/L, 5.6 mmol/L, and 7.8 mmol/L to differentiate between subjects with or without retinopathy were 7.9%, 34.2%, and 6.3%, respectively, and the specificities were 96.5%, 77.1%, and 98.1%, respectively. CONCLUSION: Confirming a recent study from Australian and North American populations, the results suggest that also for the Chinese population, a uniform glycemic threshold for prevalent retinopathy does not exist.
PURPOSE: The purpose of this study was to assess the relationship between the fasting plasma glucose cutoff of 7 mmol/L and the presence of retinopathy in a population in China. METHODS: The Beijing Eye Study 2006 is a population-based study, which included 3,251 subjects aged >or= 45 years. By using fundus photographs, retinopathy was assessed according to the Early Treatment of Diabetic Retinopathy Study. RESULTS: The correlation between fasting plasma glucose concentration and retinopathy suggested a continuous relation instead of a uniform glycemic threshold for prevalent retinopathy. For the diabetes plasma glucose concentration cutoffs of 7.0 mmol/L, 5.6 mmol/L, and 7.8 mmol/L to differentiate between subjects with or without retinopathy, the sensitivities were 18.8%, 44.0%, and 15.4%, respectively, and the specificities were 94.3%, 73.8%, and 96.6%, respectively. After excluding subjects with known diabetes and/or subjects on antidiabetic treatment, the sensitivities of diabetes plasma glucose concentration cutoffs of 7.0 mmol/L, 5.6 mmol/L, and 7.8 mmol/L to differentiate between subjects with or without retinopathy were 7.9%, 34.2%, and 6.3%, respectively, and the specificities were 96.5%, 77.1%, and 98.1%, respectively. CONCLUSION: Confirming a recent study from Australian and North American populations, the results suggest that also for the Chinese population, a uniform glycemic threshold for prevalent retinopathy does not exist.
Authors: Lei Liu; Jingyang Wu; Song Yue; Jin Geng; Jie Lian; Weiping Teng; Desheng Huang; Lei Chen Journal: Int J Environ Res Public Health Date: 2015-07-10 Impact factor: 3.390