Fernando Maestu1, Evgenia Baykova2, José María Ruiz3, Pedro Montejo3, Mercedes Montenegro3, Marcos Llanero3, Elena Solesio4, Pedro Gil5, Raquel Yubero5, Nuria Paul6, Francisco Pozo2, Angel Nevado4. 1. Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain; Departamento de Psicología Básica II, Universidad Complutense de Madrid, Spain. Electronic address: fmaestuu@psi.ucm.es. 2. Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain. 3. Centro de Prevención del Deterioro Cognitivo del Ayuntamiento de Madrid, Spain. 4. Laboratory of Cognitive and Computational Neuroscience, Centre for Biomedical Technology (Technical University of Madrid and Complutense University of Madrid), Spain; Departamento de Psicología Básica II, Universidad Complutense de Madrid, Spain. 5. Hospital Universitario San Carlos, Servicio de Geriatría Unidad de Memoria, Madrid, Spain. 6. Departamento de Psiquiatría, Universidad Complutense de Madrid, Spain.
Abstract
OBJECTIVE: Subjective memory complaints (SMCs) are frequently reported by elderly people with or without objective cognitive impairment (OMI) as assessed by neuropsychological tests. We investigate whether SMCs are associated with altered brain biomagnetic patterns even in the absence of OMI. METHODS: We report spatio-temporal patterns of brain magnetic activity recorded with magnetoencephalography during a memory task in 51 elderly participants divided into the following groups: patients with mild cognitive impairment (MCI) with SMC and OMI, individuals with SMC but not OMI, and healthy controls without neither SMC nor OMI. Exclusion criteria for all three groups included a diagnosis of depression or any other psychiatric condition. RESULTS: No statistically significant differences were found between MCI patients and participants with SMC. However, the SMC showed higher activation, between 200 and 900 ms after stimulus onset, than the control group in posterior ventral regions and in the dorsal pathway. MCI patients showed higher activation than the control group in the posterior part of the ventral pathway. CONCLUSIONS: These findings suggest that similar physiological mechanisms may underlie SMC and MCI, which could be two stages in a cognitive continuum. SIGNIFICANCE: MEG provide different neurophysiological profiles between SMC and control subjects.
OBJECTIVE: Subjective memory complaints (SMCs) are frequently reported by elderly people with or without objective cognitive impairment (OMI) as assessed by neuropsychological tests. We investigate whether SMCs are associated with altered brain biomagnetic patterns even in the absence of OMI. METHODS: We report spatio-temporal patterns of brain magnetic activity recorded with magnetoencephalography during a memory task in 51 elderly participants divided into the following groups: patients with mild cognitive impairment (MCI) with SMC and OMI, individuals with SMC but not OMI, and healthy controls without neither SMC nor OMI. Exclusion criteria for all three groups included a diagnosis of depression or any other psychiatric condition. RESULTS: No statistically significant differences were found between MCI patients and participants with SMC. However, the SMC showed higher activation, between 200 and 900 ms after stimulus onset, than the control group in posterior ventral regions and in the dorsal pathway. MCI patients showed higher activation than the control group in the posterior part of the ventral pathway. CONCLUSIONS: These findings suggest that similar physiological mechanisms may underlie SMC and MCI, which could be two stages in a cognitive continuum. SIGNIFICANCE: MEG provide different neurophysiological profiles between SMC and control subjects.
Authors: Ricardo Bajo; Nazareth P Castellanos; Maria Eugenia López; José María Ruiz; Pedro Montejo; Mercedes Montenegro; Marcos Llanero; Pedro Gil; Raquel Yubero; Evgenia Baykova; Nuria Paul; Sara Aurtenetxe; Francisco Del Pozo; Fernando Maestu Journal: Age (Dordr) Date: 2011-04-06
Authors: Edward Zamrini; Fernando Maestu; Eero Pekkonen; Michael Funke; Jyrki Makela; Myles Riley; Ricardo Bajo; Gustavo Sudre; Alberto Fernandez; Nazareth Castellanos; Francisco Del Pozo; C J Stam; Bob W van Dijk; Anto Bagic; James T Becker Journal: Int J Alzheimers Dis Date: 2011-04-10