OBJECTIVES: This study was designed to compare the effects of transcervical chorionic villus sampling (CVS) and amniocentesis on the prevalence of hemangiomas of infancy. METHODS: This is a cohort study of 250 consecutive assessable transabdominal amniocentesis procedures and 250 consecutive assessable transcervical CVS procedures performed between January and September 2002. Parents were asked to fill out a questionnaire regarding the presence of any type of skin lesions. Based on the responses to the questionnaire, children were invited to undergo a physical examination to confirm hemangiomas. RESULTS: Questionnaires were returned in 78% of the CVS group (195/250) and in 72% of the amniocentesis group (180/250). Based on the responses in the questionnaire, 78 children in the CVS group and 42 in the amniocentesis group underwent a physical examination. One or more hemangiomas were present in 53 of 195 (27.2%) children in the CVS group versus 17 of 180 (9.4%) children in the amniocentesis group (odds ratio 3.6, 95% CI: 2.0-6.5). There was no difference in congenital abnormalities between the two groups. CONCLUSION: Transcervical CVS is associated with a significantly increased prevalence of hemangiomas compared with amniocentesis. The clinical features of these hemangiomas do not differ from natural hemangiomas and complications of these hemangiomas are very rare.
OBJECTIVES: This study was designed to compare the effects of transcervical chorionic villus sampling (CVS) and amniocentesis on the prevalence of hemangiomas of infancy. METHODS: This is a cohort study of 250 consecutive assessable transabdominal amniocentesis procedures and 250 consecutive assessable transcervical CVS procedures performed between January and September 2002. Parents were asked to fill out a questionnaire regarding the presence of any type of skin lesions. Based on the responses to the questionnaire, children were invited to undergo a physical examination to confirm hemangiomas. RESULTS: Questionnaires were returned in 78% of the CVS group (195/250) and in 72% of the amniocentesis group (180/250). Based on the responses in the questionnaire, 78 children in the CVS group and 42 in the amniocentesis group underwent a physical examination. One or more hemangiomas were present in 53 of 195 (27.2%) children in the CVS group versus 17 of 180 (9.4%) children in the amniocentesis group (odds ratio 3.6, 95% CI: 2.0-6.5). There was no difference in congenital abnormalities between the two groups. CONCLUSION: Transcervical CVS is associated with a significantly increased prevalence of hemangiomas compared with amniocentesis. The clinical features of these hemangiomas do not differ from natural hemangiomas and complications of these hemangiomas are very rare.
Authors: Maria I New; Yu K Tong; Tony Yuen; Peiyong Jiang; Christian Pina; K C Allen Chan; Ahmed Khattab; Gary J W Liao; Mabel Yau; Se-Min Kim; Rossa W K Chiu; Li Sun; Mone Zaidi; Y M Dennis Lo Journal: J Clin Endocrinol Metab Date: 2014-02-28 Impact factor: 5.958
Authors: James R Dornhoffer; Ting Wei; Haihong Zhang; Emily Miller; Mario A Cleves; Gresham T Richter Journal: Pediatr Res Date: 2017-05-03 Impact factor: 3.756
Authors: Laura Macca; Domenica Altavilla; Luca Di Bartolomeo; Natasha Irrera; Francesco Borgia; Federica Li Pomi; Federico Vaccaro; Violetta Squadrito; Francesco Squadrito; Mario Vaccaro Journal: Front Pharmacol Date: 2022-05-26 Impact factor: 5.988
Authors: Graham M Strub; Andrew L Kirsh; Mark E Whipple; Winston P Kuo; Rachel B Keller; Raj P Kapur; Mark W Majesky; Jonathan A Perkins Journal: JCI Insight Date: 2016-09-08
Authors: Chelsey J F Smith; Kenneth L Jones; Diana L Johnson; Gretchen Bandoli; Loan K Robinson; Arthur Kavanaugh; Christina D Chambers Journal: Am J Med Genet A Date: 2018-01-17 Impact factor: 2.802