Literature DB >> 20824030

Vacuum-Sealing as a Treatment Option for Severe Anthracycline Extravasation in a Breast Cancer Patient.

Kerstin Rhiem1, André T Nemat, Rita K Schmutzler, Matthias Krick, Peter Mallmann, Mathias Warm.   

Abstract

BACKGROUND: Compared to peripheral venous access, central lines greatly reduce the incidence of cytotoxic extravasation. Although implantable vascular systems are widely used in oncology, extended extravasation lesions in cancer patients remain complicated. PATIENT AND
METHOD: A 67-year-old female breast cancer patient suffered from an extended lesion of a catheter port extravasation. A vacuum-sealing therapy was initiated to accelerate the healing of the anthracycline-induced wound. RESULT: The vacuum-sealing technique allowed a fast and successful treatment of the extravasation lesion.
CONCLUSION: Due to the myelosuppressive chemotherapy regimen, the risk of wound infections and prolonged healing processes is increased in cancer patients. Moreover, disruption or cancellation of anticancer therapies worsens the patients' prognosis. To attenuate these complications the vacuum-sealing technique should be considered in wound management concepts.

Entities:  

Year:  2008        PMID: 20824030      PMCID: PMC2931107          DOI: 10.1159/000154141

Source DB:  PubMed          Journal:  Breast Care (Basel)        ISSN: 1661-3791            Impact factor:   2.860


  6 in total

1.  Retrospective study of the management of chemotherapeutic extravasation injury.

Authors:  Howard N Langstein; Haluk Duman; Deborah Seelig; Charles E Butler; Gregory R D Evans
Journal:  Ann Plast Surg       Date:  2002-10       Impact factor: 1.539

2.  Long persistence of doxorubicin in human skin after extravasation.

Authors:  P Sonneveld; H A Wassenaar; K Nooter
Journal:  Cancer Treat Rep       Date:  1984-06

3.  Treatment of anthracycline extravasation with Savene (dexrazoxane): results from two prospective clinical multicentre studies.

Authors:  H T Mouridsen; S W Langer; J Buter; H Eidtmann; G Rosti; M de Wit; P Knoblauch; A Rasmussen; K Dahlstrøm; P B Jensen; G Giaccone
Journal:  Ann Oncol       Date:  2006-12-21       Impact factor: 32.976

4.  Use of totally implantable central venous access ports for high-dose chemotherapy and peripheral blood stem cell transplantation: results of a monocentre series of 376 patients.

Authors:  R Biffi; S Pozzi; A Agazzi; U Pace; A Floridi; S Cenciarelli; V Peveri; A Cocquio; B Andreoni; G Martinelli
Journal:  Ann Oncol       Date:  2004-02       Impact factor: 32.976

5.  Dexrazoxane (Totect): FDA review and approval for the treatment of accidental extravasation following intravenous anthracycline chemotherapy.

Authors:  Robert C Kane; W David McGuinn; Ramzi Dagher; Robert Justice; Richard Pazdur
Journal:  Oncologist       Date:  2008-04

Review 6.  Topical negative pressure for treating chronic wounds.

Authors:  Dirk T Ubbink; Stijn Joël Westerbos; Debra Evans; Lucy Land; Hester Vermeulen
Journal:  Cochrane Database Syst Rev       Date:  2008-07-16
  6 in total

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