| Literature DB >> 20823925 |
N V Galaĭko, I A Tolmacheva, V V Grishko, L V Volkova, E N Prevozchikova, S A Pestereva.
Abstract
Novel hydrazones of lupane and 19beta,28-epoxy-18alpha-oleanane type have been synthesized via interaction of 2,3-secotriterpenic aldehydonitriles with substituted hydrazines. As a result of investigation of 2,3-secotriterpenic hydrazones antiviral activity to the strain "Indiana" of vesicular stomatitis virus on two models of mammal's line cell infection, acetylhydrazone 1-cyano-2,3-seco-19beta,28-epoxy-18alpha-olean-3-al has been found to have a high prophylactic activity 0.00016 microg/ml to vesicular stomatitis virus and to inhibit a virus reproduction in primarily infected cells in 0.21 microg/ml concentration.Entities:
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Year: 2010 PMID： 20823925
Source DB: PubMed Journal: Bioorg Khim ISSN： 0132-3423