Photoaging: the role of oxidative stress.

Our skin suffers from daily exposure to oxidative stress, primarily from exposure to the sun's damaging ultraviolet (UV) rays. This results in the appearance of premature aging. The mechanisms of this photodamage to all layers of the skin by the various wavelengths (UVB and UVA) will be clarified. Recent research further demonstrates a synergistic enhancement of oxidative damage when the skin is exposed to UVA in combination with environmental urban pollutants (including cigarette smoke). The fact that photoaging is largely caused by oxidative damage is confirmed by the demonstration that treatment with topical antioxidants can prevent and even partially reverse UV-induced photodamage. Research substantiating the efficacy of vitamins C and E and of selenium will be reviewed.