Literature DB >> 20823544

Crystallization and preliminary X-ray diffraction analysis of rat autotaxin.

Jacqueline E Day1, Troii Hall, Lyle E Pegg, Timothy E Benson, Jens Hausmann, Satwik Kamtekar.   

Abstract

Rat autotaxin has been cloned, expressed, purified to homogeneity and crystallized via hanging-drop vapour diffusion using PEG 3350 as precipitant and ammonium iodide and sodium thiocyanate as salts. The crystals diffracted to a maximum resolution of 2.05 A and belonged to space group P1, with unit-cell parameters a=53.8, b=63.3, c=70.5 A, alpha=98.8, beta=106.2, gamma=99.8 degrees. Preliminary X-ray diffraction analysis indicated the presence of one molecule per asymmetric unit, with a solvent content of 47%.

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Year:  2010        PMID： 20823544      PMCID： PMC2935245          DOI： 10.1107/S1744309110030228

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


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  5 in total

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5.  Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.

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  5 in total

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