Investigation on the optimal position for the quantification of hepatic perfusion by use of dynamic contrast-enhanced computed tomography in rats.

Our purpose in this study was to investigate the optimal position for the quantification of hepatic perfusion by using a dual-input, single-compartment model and dynamic contrast-enhanced computed tomography (DCE-CT) in rats. The DCE-CT studies were performed with the animals in the supine and prone position, with an interval of 1 day, on six male Sprague-Dawley rats. The distance between the inferior vena cava (IVC) and portal vein was calculated. The arterial hepatic blood flow (AHBF) and portal hepatic blood flow (PHBF) were also estimated by use of time-density curves (TDCs) in the aorta, portal vein, and liver. The distance between the IVC and portal vein in the supine position (3.68 +/- 0.22 mm) was significantly greater than that in the prone position (2.56 +/- 0.19 mm). The estimated AHBF (102.1 +/- 8.9 ml/100 ml/min) and PHBF values (114.8 +/- 19.7 ml/100 ml/min) in the prone position were significantly overestimated and underestimated, respectively, as compared to those in the supine position (76.1 +/- 4.2 ml/100 ml/min for AHBF and 235.1 +/- 17.3 ml/100 ml/min for PHBF). We concluded that the supine position was more appropriate than the prone position for the quantification of hepatic perfusion by use of a dual-input, single-compartment model and DCE-CT in rats, because the TDC in the portal vein is affected less by the TDC in the IVC in the supine position than in the prone position.