OBJECTIVE: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. METHODS: Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. RESULTS: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥ 560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. CONCLUSION: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
OBJECTIVE: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. METHODS: Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. RESULTS: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥ 560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. CONCLUSION: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.
Authors: B C Blount; M M Mack; C M Wehr; J T MacGregor; R A Hiatt; G Wang; S N Wickramasinghe; R B Everson; B N Ames Journal: Proc Natl Acad Sci U S A Date: 1997-04-01 Impact factor: 11.205
Authors: Eric J Jacobs; Cari J Connell; Ann Chao; Marjorie L McCullough; Carmen Rodriguez; Michael J Thun; Eugenia E Calle Journal: Am J Epidemiol Date: 2003-10-01 Impact factor: 4.897
Authors: Jung Eun Lee; Walter C Willett; Charles S Fuchs; Stephanie A Smith-Warner; Kana Wu; Jing Ma; Edward Giovannucci Journal: Am J Clin Nutr Date: 2011-01-26 Impact factor: 7.045
Authors: Tim Y Hou; Laurie A Davidson; Eunjoo Kim; Yang-Yi Fan; Natividad R Fuentes; Karen Triff; Robert S Chapkin Journal: Annu Rev Nutr Date: 2016-07-17 Impact factor: 11.848
Authors: Josiane Steluti; Christina Reginaldo; Jacob Selhub; Ligi Paul; Regina Mara Fisberg; Dirce Maria Marchioni Journal: Eur J Nutr Date: 2018-11-02 Impact factor: 5.614
Authors: Todd M Gibson; Stephanie J Weinstein; Ruth M Pfeiffer; Albert R Hollenbeck; Amy F Subar; Arthur Schatzkin; Susan T Mayne; Rachael Stolzenberg-Solomon Journal: Am J Clin Nutr Date: 2011-08-03 Impact factor: 7.045
Authors: Marian L Neuhouser; Ting-Yuan David Cheng; Shirley A A Beresford; Elissa Brown; Xiaoling Song; Joshua W Miller; Yingye Zheng; Cynthia A Thomson; James M Shikany; Mara Z Vitolins; Thomas Rohan; Ralph Green; Cornelia M Ulrich Journal: Int J Cancer Date: 2015-02-24 Impact factor: 7.396
Authors: Stefanie Zschäbitz; Ting-Yuan David Cheng; Marian L Neuhouser; Yingye Zheng; Roberta M Ray; Joshua W Miller; Xiaoling Song; David R Maneval; Shirley A A Beresford; Dorothy Lane; James M Shikany; Cornelia M Ulrich Journal: Am J Clin Nutr Date: 2012-12-19 Impact factor: 7.045
Authors: Anthony A Razzak; Amy S Oxentenko; Robert A Vierkant; Lori S Tillmans; Alice H Wang; Daniel J Weisenberger; Peter W Laird; Charles F Lynch; Kristin E Anderson; Amy J French; Robert W Haile; Lisa J Harnack; John D Potter; Susan L Slager; Thomas C Smyrk; Stephen N Thibodeau; James R Cerhan; Paul J Limburg Journal: Nutr Cancer Date: 2012 Impact factor: 2.900